{"id":"W3094227461","doi":"10.14309/01.ajg.0000705596.11276.6f","title":"S0887 Fecal Calprotectin as a Surrogate Marker of Clinical Remission, Clinical Response, Endoscopic Improvement, and Histo-Endoscopic Mucosal Healing: UNIFI Induction Study","year":2020,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"","keywords":"Medicine; Calprotectin; Internal medicine; Gastroenterology; Receiver operating characteristic; Area under the curve; Clinical trial; Placebo; Surrogate endpoint; Randomized controlled trial; Surgery; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007729447,0.001161752,0.001971621,0.0004988536,0.0002944455,0.0009070643,0.0006153968,0.001221868,0.004950759],"category_scores_gemma":[0.003053362,0.0003837645,0.001311965,0.0006646367,0.0007688474,0.000619466,0.0004785057,0.002105548,0.001170366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000378205,"about_ca_system_score_gemma":0.001110711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001953902,"about_ca_topic_score_gemma":0.0003522791,"domain_scores_codex":[0.9980731,0.001106564,0.0001571031,0.000205611,0.0003473257,0.0001103077],"domain_scores_gemma":[0.9967294,0.00100343,0.0009828184,0.0003559189,0.0002449767,0.0006834262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8241086,0.01784771,0.0397786,0.001337246,0.002652677,0.0001565957,0.0001578893,0.0006255931,0.01537274,0.0002213824,0.003377612,0.09436332],"study_design_scores_gemma":[0.2403449,0.5915465,0.1447646,0.0002274,0.003211874,0.0006096595,0.00006795838,0.002288893,0.01109868,0.000274353,0.005495277,0.00006993944],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835587,0.00730504,0.001128951,0.0005230088,0.0001793979,0.002320519,0.001899188,0.000143882,0.002941278],"genre_scores_gemma":[0.9890699,0.001780356,0.002041723,0.0007214742,0.0003504504,0.001894454,0.002096903,0.00002142844,0.00202329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007729447,"threshold_uncertainty_score":0.0408777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02751983526168131,"score_gpt":0.3389769052455412,"score_spread":0.3114570699838599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}