{"id":"W3094285965","doi":"10.1038/s41598-020-74934-9","title":"Unravelling the antimicrobial action of antidepressants on gut commensal microbes","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":163,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Mitacs","keywords":"Antimicrobial; Akkermansia muciniphila; Microbiology; Bacteroides fragilis; Antidepressant; Gut flora; Aripiprazole; Biology; Pharmacology; Desipramine; Citalopram; Bacteroides; Antibiotics; Medicine; Bacteria; Anxiety; Schizophrenia (object-oriented programming); Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002781457,0.000370085,0.0003595696,0.0003692848,0.0001437343,0.0007848354,0.0002578377,0.0005886298,0.0006457652],"category_scores_gemma":[0.0002736457,0.0001173062,0.0002135285,0.0002912198,0.0003264996,0.0007737936,0.0003836323,0.000658981,0.0002114244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000164679,"about_ca_system_score_gemma":0.0004387857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004295773,"about_ca_topic_score_gemma":0.0007234135,"domain_scores_codex":[0.9998362,0.00004675335,0.0000160136,0.00002948517,0.00004660648,0.00002495605],"domain_scores_gemma":[0.9998351,0.00003498115,0.00006262043,0.00001300954,0.00003576927,0.00001856875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000317564,0.0001556492,0.009753311,0.002477465,0.00008485096,0.0009122642,0.000249536,0.0006472294,0.7668104,0.002472426,0.001195454,0.2149238],"study_design_scores_gemma":[0.00007420118,0.003531098,0.260407,0.002281214,0.0005547391,0.007825437,0.003743941,0.0107809,0.4518563,0.0131889,0.245629,0.0001272249],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.4587848,0.5145625,0.01320448,0.005968167,0.0004327077,0.0000576121,0.0005590759,0.0000935747,0.006337114],"genre_scores_gemma":[0.7461767,0.2349658,0.01450511,0.001348891,0.0004247462,0.00004465769,0.0003235461,0.00001392783,0.002196726],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0007848354,"threshold_uncertainty_score":0.002160251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03583478413596163,"score_gpt":0.286698898509497,"score_spread":0.2508641143735353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}