{"id":"W3094285965","doi":"10.1038/s41598-020-74934-9","title":"Unravelling the antimicrobial action of antidepressants on gut commensal microbes","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":163,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Mitacs","keywords":"Antimicrobial; Akkermansia muciniphila; Microbiology; Bacteroides fragilis; Antidepressant; Gut flora; Aripiprazole; Biology; Pharmacology; Desipramine; Citalopram; Bacteroides; Antibiotics; Medicine; Bacteria; Anxiety; Schizophrenia (object-oriented programming); Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003914995,0.0001043178,0.0001260964,0.00002932869,0.000251101,0.0000573194,0.0001422836,0.00007579008,0.00001999745],"category_scores_gemma":[0.00005955733,0.00007800863,0.00008497732,0.0001412635,0.0002015417,0.000003603772,0.0000827602,0.00009703357,0.00001075898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004771574,"about_ca_system_score_gemma":0.0001020089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002137386,"about_ca_topic_score_gemma":0.00001234121,"domain_scores_codex":[0.9988499,0.00005045953,0.0003150582,0.0004580464,0.0001261086,0.0002004819],"domain_scores_gemma":[0.9991457,0.000007892399,0.0002337043,0.000454505,0.00009258962,0.0000655551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003185359,0.00003623598,0.001780831,0.00003161512,0.0000134279,0.000009907204,0.0001259571,0.0001211632,0.9488584,0.000006681104,0.04872135,0.0002625769],"study_design_scores_gemma":[0.0001086194,0.00006855399,0.001382914,0.00002102042,0.000009558157,0.00004197568,0.00004662095,0.0000304479,0.9330572,0.0000213692,0.0651284,0.00008333239],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962327,0.00009428237,0.0002808207,0.001052083,0.001791521,0.0001892264,0.000009596305,0.00001030182,0.0003394388],"genre_scores_gemma":[0.9985383,0.0000313357,0.0001680428,0.0006871231,0.000162598,0.000001496242,0.00009998064,0.00001197347,0.0002991824],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01640706,"threshold_uncertainty_score":0.31811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03583478413596163,"score_gpt":0.286698898509497,"score_spread":0.2508641143735353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}