{"id":"W3094290388","doi":"10.1200/jco.20.02510","title":"Selection of Optimal Adjuvant Chemotherapy and Targeted Therapy for Early Breast Cancer: ASCO Guideline Update","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cancer Care Ontario; Sunnybrook Health Science Centre; Amgen (Canada)","funders":"","keywords":"Medicine; Trastuzumab; Breast cancer; Oncology; Trastuzumab emtansine; Internal medicine; Guideline; Hazard ratio; Targeted therapy; Adjuvant therapy; Cancer; Chemotherapy; Pathology; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005373803,0.0001280476,0.0007146837,0.00001867627,0.00003648635,0.000004437588,0.0001165056,0.0002125998,0.00003320908],"category_scores_gemma":[0.0001901183,0.00009447365,0.0002512955,0.00006003692,0.0001400528,0.000007454095,0.00003263915,0.0001573711,3.652553e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002070623,"about_ca_system_score_gemma":0.0004394724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003407581,"about_ca_topic_score_gemma":0.00001640638,"domain_scores_codex":[0.9983292,0.0001029171,0.001119394,0.0001974363,0.0001065765,0.0001444545],"domain_scores_gemma":[0.9981298,0.0001007376,0.001026937,0.00006755092,0.0005337998,0.0001411258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.04476908,0.001130705,0.2208618,0.00003432051,0.003083527,0.00001013959,0.0002231018,0.0002149583,0.0610134,0.00002437572,0.03637546,0.6322591],"study_design_scores_gemma":[0.02365975,0.02011926,0.7053187,0.00002813568,0.0002662038,0.0001254924,0.00009216538,0.0003379217,0.03103701,0.00007151692,0.2186914,0.0002524277],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9682567,0.002964056,0.001610423,0.02660845,0.000278945,0.0001720473,0.00008204287,0.000003822485,0.00002357931],"genre_scores_gemma":[0.9732338,0.01218048,0.008698599,0.004095703,0.001741748,0.000009785407,0.000009967755,0.00001917974,0.00001074864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6320067,"threshold_uncertainty_score":0.3852524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.044419927553881,"score_gpt":0.4085744963709148,"score_spread":0.3641545688170337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}