{"id":"W3094290388","doi":"10.1200/jco.20.02510","title":"Selection of Optimal Adjuvant Chemotherapy and Targeted Therapy for Early Breast Cancer: ASCO Guideline Update","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cancer Care Ontario; Sunnybrook Health Science Centre; Amgen (Canada)","funders":"","keywords":"Medicine; Trastuzumab; Breast cancer; Oncology; Trastuzumab emtansine; Internal medicine; Guideline; Hazard ratio; Targeted therapy; Adjuvant therapy; Cancer; Chemotherapy; Pathology; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03266599,0.001667232,0.004243832,0.006517462,0.001173231,0.004196617,0.006764284,0.00564482,0.002671291],"category_scores_gemma":[0.07905442,0.0009357901,0.004542416,0.0074652,0.001418653,0.002686875,0.002928519,0.006574952,0.001904665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.008255752,"about_ca_system_score_gemma":0.03964643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.04039666,"about_ca_topic_score_gemma":0.07534327,"domain_scores_codex":[0.9689059,0.01338978,0.009361137,0.001002972,0.006354039,0.0009861983],"domain_scores_gemma":[0.9141803,0.02332902,0.0103011,0.001791819,0.04769218,0.002705561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001655509,0.0001501315,0.002476449,0.0367302,0.0008124116,0.0001775031,0.0004955017,0.001237372,0.0004721991,0.004379029,0.5886719,0.3642316],"study_design_scores_gemma":[0.0005636137,0.0002048595,0.005169269,0.1518509,0.002624799,0.0004305395,0.000475928,0.0013167,0.000508604,0.006952278,0.829755,0.0001475212],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003615419,0.5852912,0.01147391,0.3487751,0.01507412,0.003073398,0.005844684,0.0004809606,0.02637134],"genre_scores_gemma":[0.02901514,0.6787872,0.1157183,0.1411579,0.009966373,0.005044221,0.01479483,0.0003505759,0.005165508],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.04039666,"threshold_uncertainty_score":0.1727563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.044419927553881,"score_gpt":0.4085744963709148,"score_spread":0.3641545688170337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}