{"id":"W3094306108","doi":"10.1016/j.molmet.2020.101106","title":"Extracellular serine and glycine are required for mouse and human skeletal muscle stem and progenitor cell function","year":2020,"lang":"en","type":"article","venue":"Molecular Metabolism","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Biomedical Imaging and Bioengineering; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of General Medical Sciences; American Federation for Aging Research; Canadian Institutes of Health Research; National Institute on Aging; National Cancer Institute; National Institutes of Health; National Science Foundation","keywords":"Glycine; Skeletal muscle; Serine; Biology; Population; Cell biology; Progenitor cell; Extracellular; Biochemistry; Amino acid; Stem cell; Endocrinology; Medicine; Phosphorylation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001963245,0.0004111614,0.0002695002,0.000334824,0.0001546535,0.0003358184,0.0002056453,0.0002980323,0.002683667],"category_scores_gemma":[0.0001912106,0.0001686103,0.0002638846,0.0002209802,0.0002419817,0.0001753335,0.0002466657,0.000339484,0.0009293261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002021736,"about_ca_system_score_gemma":0.0003070488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006666241,"about_ca_topic_score_gemma":0.000950388,"domain_scores_codex":[0.9997712,0.00003982826,0.00003803286,0.00005573975,0.00006765324,0.00002752274],"domain_scores_gemma":[0.9997641,0.00003947366,0.00009602925,0.0000277746,0.00002032771,0.0000521873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001844452,0.00001095436,0.0002584012,0.00004636254,0.000005024758,0.0001261826,0.00001126327,0.00003076655,0.9981245,0.00005797319,0.00003617363,0.001108018],"study_design_scores_gemma":[0.00002195891,0.0002904198,0.01375624,0.00001690862,0.00003475418,0.00133627,0.00004116609,0.0003590578,0.9751905,0.00005263487,0.008894065,0.000006012016],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828828,0.005862599,0.005241893,0.0001603994,0.00003798692,0.00006165804,0.00287981,0.0002017839,0.002671049],"genre_scores_gemma":[0.9807308,0.002585574,0.006679403,0.00009486567,0.00001643583,0.0001562363,0.004953204,0.00007246352,0.004710936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002683667,"threshold_uncertainty_score":0.008977771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01104090495016196,"score_gpt":0.2196492179495238,"score_spread":0.2086083129993619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}