{"id":"W3094391173","doi":"10.21203/rs.3.rs-94837/v1","title":"SARS-CoV-2 candidate vaccine ChAdOx1 nCoV-19 infection of human cell lines reveals a normal low range of viral backbone gene expression alongside very high levels of SARS-CoV-2 S glycoprotein expression.","year":2020,"lang":"en","type":"preprint","venue":"Research Square","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Engineering and Physical Sciences Research Council; U.S. Food and Drug Administration; Hamilton Health Sciences Foundation","keywords":"Virology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Biology; Coronavirus disease 2019 (COVID-19); Coronavirus; 2019-20 coronavirus outbreak; Gene; Medicine; Infectious disease (medical specialty); Genetics; Outbreak; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.003912788,0.001128961,0.003258132,0.002521383,0.0003452515,0.00009891693,0.001419271,0.00148713,0.00009156314],"category_scores_gemma":[0.002387506,0.001007659,0.001033603,0.00182229,0.000616184,0.0004159912,0.003763885,0.003834202,0.00006421469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006648249,"about_ca_system_score_gemma":0.002234348,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02193652,"about_ca_topic_score_gemma":0.0005620865,"domain_scores_codex":[0.9868287,0.001842667,0.002820338,0.002036836,0.004728784,0.001742711],"domain_scores_gemma":[0.9908394,0.0007113082,0.001460998,0.002906795,0.003812785,0.0002687561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006724196,0.001460519,0.02177789,0.02563767,0.0002522969,0.0005324337,0.001024432,0.00001568348,0.9370444,0.00001571325,0.004969693,0.0005450235],"study_design_scores_gemma":[0.00760821,0.002732696,0.01552648,0.009769442,0.0001382043,0.00003276767,0.00009916347,0.0001785876,0.9618291,0.0007416455,0.0006343376,0.0007094032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890852,0.002465921,0.000550682,0.0003479695,0.0003347384,0.005398841,0.001228744,0.0001589432,0.0004289844],"genre_scores_gemma":[0.9952354,0.0002820679,0.001161541,0.0007399294,0.001163029,0.0007201989,0.0003382604,0.0002665339,0.00009303569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02478461,"threshold_uncertainty_score":0.9998091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09542750500904279,"score_gpt":0.4050890700716733,"score_spread":0.3096615650626305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}