{"id":"W3094391173","doi":"10.21203/rs.3.rs-94837/v1","title":"SARS-CoV-2 candidate vaccine ChAdOx1 nCoV-19 infection of human cell lines reveals a normal low range of viral backbone gene expression alongside very high levels of SARS-CoV-2 S glycoprotein expression.","year":2020,"lang":"en","type":"preprint","venue":"Research Square","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Engineering and Physical Sciences Research Council; U.S. Food and Drug Administration; Hamilton Health Sciences Foundation","keywords":"Virology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Biology; Coronavirus disease 2019 (COVID-19); Coronavirus; 2019-20 coronavirus outbreak; Gene; Medicine; Infectious disease (medical specialty); Genetics; Outbreak; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001195434,0.0002904515,0.0001832876,0.0001600051,0.0001346802,0.0003679715,0.00008533698,0.0003037239,0.005532945],"category_scores_gemma":[0.0001609463,0.0000985611,0.0001619354,0.0001475948,0.0001683398,0.0001556865,0.000127119,0.0004368184,0.002025158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000234529,"about_ca_system_score_gemma":0.0001880875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009573733,"about_ca_topic_score_gemma":0.0008705432,"domain_scores_codex":[0.9998991,0.00001764697,0.000006674036,0.00001786126,0.00002902527,0.00002952732],"domain_scores_gemma":[0.9999547,0.00001375499,0.000006164229,0.000008821223,0.000008855114,0.000007740955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001601853,0.00002218194,0.0002641217,0.00002443189,0.000003936081,0.00006607188,0.00001842131,0.00003758285,0.9971584,0.0002296338,0.0004665682,0.001548389],"study_design_scores_gemma":[0.00002658856,0.0002595984,0.009486725,0.000007813005,0.000009509918,0.0005418009,0.00005511427,0.0007067825,0.9778658,0.0001628184,0.01087347,0.000004001044],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9623796,0.002812368,0.006849914,0.0007568441,0.0002077128,0.0000703538,0.006512584,0.0003538781,0.02005658],"genre_scores_gemma":[0.9598235,0.001583447,0.004248727,0.0001763907,0.00003620965,0.00005755225,0.01229312,0.00009757233,0.02168355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005532945,"threshold_uncertainty_score":0.01850957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09542750500904279,"score_gpt":0.4050890700716733,"score_spread":0.3096615650626305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}