{"id":"W3094426283","doi":"10.23934/2223-9022-2020-9-3-391-399","title":"The Effect of Polymorphisms in the CYP2D6 and CYP2C9 Genes on the Clinical Efficacy of Tramadol and Ketorolac When Using the Accelerated Recovery Protocol in Patients With Uncomplicated Acute Calculous Cholecystitis Who Underwent Cholecystectomy","year":2020,"lang":"en","type":"article","venue":"Russian Sklifosovsky Journal Emergency Medical Care","topic":"Anesthesia and Pain Management","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Tramadol; Analgesic; CYP2D6; Pharmacogenomics; Pharmacogenetics; Ketorolac; Anesthesia; Visual analogue scale; Adverse effect; Metamizole; Perioperative; CYP2C9; Codeine; Pharmacology; Internal medicine; Morphine; Genotype","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002113878,0.0003190958,0.0006558048,0.00008452933,0.0002985113,0.00004842002,0.0005245599,0.0001772995,0.0001222929],"category_scores_gemma":[0.0005138055,0.000119971,0.0001769985,0.0005457182,0.0004173826,0.00006614887,0.000082901,0.001157305,0.000001317057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006544442,"about_ca_system_score_gemma":0.0001953846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007693038,"about_ca_topic_score_gemma":0.00003884404,"domain_scores_codex":[0.9950639,0.001839745,0.001171241,0.0003440462,0.001206228,0.0003748483],"domain_scores_gemma":[0.9978924,0.0008042048,0.0005013295,0.0003950577,0.0001160827,0.0002908998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01125645,0.0003618989,0.9413886,0.0004423984,0.0006373643,0.0002824883,0.004968782,0.00006512996,0.00004136074,0.0001540371,0.00139354,0.03900792],"study_design_scores_gemma":[0.01489673,0.006288011,0.9718147,0.001310841,0.0004105376,0.000106788,0.0009786236,0.0008908495,0.0001072183,0.00004987744,0.002912861,0.0002329861],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.963513,0.0005247067,0.0000811367,0.01871093,0.0000686804,0.01692561,0.000006397178,0.00000997525,0.000159616],"genre_scores_gemma":[0.9969557,0.0002696914,0.00002139715,0.001708282,0.0001740877,0.0008243869,0.000007358092,0.0000289437,0.00001013958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03877493,"threshold_uncertainty_score":0.5027977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03113734697459937,"score_gpt":0.3276080946440252,"score_spread":0.2964707476694259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}