{"id":"W3094434047","doi":"10.14309/01.ajg.0000706328.53076.1a","title":"S1070 A Phase 3 Study Comparing Switching: Tenofovir Disoproxil Fumarate (TDF) to Tenofovir Alafenamide (TAF) With Continued TDF Treatment in Virologically Suppressed Patients With Chronic Hepatitis B: Final Week 96 Results","year":2020,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Society of Intestinal Research; Toronto Liver Centre; Toronto General Hospital; University of British Columbia","funders":"","keywords":"Tenofovir alafenamide; Medicine; Placebo; Internal medicine; Creatinine; Urology; Adverse effect; Randomized controlled trial; Tenofovir; Gastroenterology; Viral load; Immunology; Virus; Human immunodeficiency virus (HIV); Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001671501,0.0008577806,0.001517809,0.0003646709,0.0003903722,0.0007317991,0.000779058,0.001182712,0.007167558],"category_scores_gemma":[0.0009333551,0.0004524474,0.001471911,0.0003036089,0.0007604304,0.0005335034,0.0002636563,0.002251633,0.001080556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006553428,"about_ca_system_score_gemma":0.001449191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001118828,"about_ca_topic_score_gemma":0.002343749,"domain_scores_codex":[0.999478,0.0002522396,0.00004036939,0.00008093486,0.00006617464,0.00008234083],"domain_scores_gemma":[0.9992005,0.0001903193,0.0001656003,0.00006264768,0.00007184147,0.0003091415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8947139,0.02925229,0.003153033,0.0004842153,0.0009968447,0.0001243531,0.0001603981,0.0005585137,0.02358348,0.0001283409,0.001651621,0.04519309],"study_design_scores_gemma":[0.6751139,0.3145438,0.005830686,0.00003471524,0.0003892495,0.0001087136,0.00003154565,0.0004595725,0.00237191,0.00008350889,0.001012407,0.00002000316],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930533,0.0009832314,0.0004345323,0.0002379683,0.0000911833,0.002637375,0.001216704,0.00007592292,0.001269894],"genre_scores_gemma":[0.9906638,0.0007034749,0.001604397,0.0005494698,0.0001378796,0.002919544,0.001516989,0.00002350928,0.001880889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007167558,"threshold_uncertainty_score":0.02397782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02828883685798927,"score_gpt":0.2764455892515854,"score_spread":0.2481567523935961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}