{"id":"W3094435518","doi":"10.1038/s41467-020-19111-2","title":"Cerebral small vessel disease genomics and its implications across the lifespan","year":2020,"lang":"en","type":"review","venue":"Nature Communications","topic":"Cerebrovascular and genetic disorders","field":"Medicine","cited_by":208,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; McGill Genome Centre; University of Ottawa","funders":"National Human Genome Research Institute; National Heart, Lung, and Blood Institute; National Institute on Aging; Biotechnology and Biological Sciences Research Council; Lundbeckfonden; National Institutes of Health; Agence Nationale de la Recherche; National Center for Research Resources; National Institute of Neurological Disorders and Stroke; Medical Research Council; National Institute for Health and Care Research","keywords":"Mendelian randomization; Genome-wide association study; Confounding; Dementia; Leukoaraiosis; Disease; Medicine; Stroke (engine); White matter; CADASIL; Hyperintensity; Genetic association; Brain size; Bioinformatics; Single-nucleotide polymorphism; Biology; Internal medicine; Genetics; Magnetic resonance imaging; Gene; Genetic variants","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008989992,0.0007567346,0.001692466,0.001866125,0.0001934502,0.0009760035,0.0007446379,0.001108797,0.003378048],"category_scores_gemma":[0.001314358,0.0002802126,0.0007068746,0.001847174,0.0003747547,0.0009615417,0.0006477883,0.001356193,0.001632522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007839974,"about_ca_system_score_gemma":0.001582273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002145739,"about_ca_topic_score_gemma":0.003449248,"domain_scores_codex":[0.9998214,0.00004223871,0.00003137621,0.00003393464,0.00005043071,0.00002075646],"domain_scores_gemma":[0.9994364,0.0003115731,0.00006885913,0.00001361404,0.0001279006,0.00004155786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001401607,0.00003197812,0.0001968646,0.02922905,0.0002797685,0.0001202747,0.00005474897,0.0003425618,0.0005891418,0.003093509,0.02726116,0.9386607],"study_design_scores_gemma":[0.00005503936,0.0001583792,0.002473735,0.01703359,0.0005821833,0.001015555,0.00008829957,0.0001316657,0.0002592216,0.003839053,0.9743329,0.00003040084],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006137851,0.999231,0.00003430741,0.0002678015,0.00009804835,0.000001858802,0.00001563136,0.000003540902,0.0002864577],"genre_scores_gemma":[0.0004104017,0.9990717,0.00006443408,0.0001746319,0.00007749762,0.000004017471,0.00002313995,8.711588e-7,0.0001732334],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003378048,"threshold_uncertainty_score":0.01130062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05484362402428115,"score_gpt":0.3693976342280037,"score_spread":0.3145540102037225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}