{"id":"W3094435518","doi":"10.1038/s41467-020-19111-2","title":"Cerebral small vessel disease genomics and its implications across the lifespan","year":2020,"lang":"en","type":"review","venue":"Nature Communications","topic":"Cerebrovascular and genetic disorders","field":"Medicine","cited_by":208,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; McGill Genome Centre; University of Ottawa","funders":"National Human Genome Research Institute; National Heart, Lung, and Blood Institute; National Institute on Aging; Biotechnology and Biological Sciences Research Council; Lundbeckfonden; National Institutes of Health; Agence Nationale de la Recherche; National Center for Research Resources; National Institute of Neurological Disorders and Stroke; Medical Research Council; National Institute for Health and Care Research","keywords":"Mendelian randomization; Genome-wide association study; Confounding; Dementia; Leukoaraiosis; Disease; Medicine; Stroke (engine); White matter; CADASIL; Hyperintensity; Genetic association; Brain size; Bioinformatics; Single-nucleotide polymorphism; Biology; Internal medicine; Genetics; Magnetic resonance imaging; Gene; Genetic variants","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001830451,0.0003334927,0.0007752972,0.00004323927,0.0005767308,0.00008491059,0.00136892,0.0004283358,0.00001533804],"category_scores_gemma":[0.0003991408,0.0002354649,0.0005153714,0.0004721258,0.0002181582,0.00002674595,0.0009828388,0.001986734,0.0000656796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007564755,"about_ca_system_score_gemma":0.0006666664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007286291,"about_ca_topic_score_gemma":0.0001519419,"domain_scores_codex":[0.9986025,0.0002035547,0.0004104788,0.0003912894,0.0001349041,0.0002572398],"domain_scores_gemma":[0.9956898,0.0003536316,0.0001922361,0.003280856,0.0001427199,0.0003407614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000008027204,0.0001820287,0.0002330731,0.003046374,0.000686187,0.000001555143,0.0004516493,3.88627e-7,6.179066e-7,0.008107991,0.004669701,0.9826124],"study_design_scores_gemma":[0.0002380505,0.00001463763,0.003435204,0.0007017666,0.002065898,0.00005059304,0.00007770091,0.00003755305,1.051116e-7,0.00009163663,0.9930706,0.0002162674],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002467482,0.9745956,0.00001798342,0.02215089,0.00008063803,0.001701106,0.0004520055,0.0000719185,0.0009051798],"genre_scores_gemma":[0.001555015,0.9942105,0.0005150518,0.001375541,0.000146653,0.0003797124,0.001470392,0.00007320493,0.0002738743],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9884009,"threshold_uncertainty_score":0.9601979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05484362402428115,"score_gpt":0.3693976342280037,"score_spread":0.3145540102037225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}