{"id":"W3094460179","doi":"10.1016/j.htct.2020.09.112","title":"Caplacizumab induces fast and durable platelet count responses with improved time to complete remission and recurrence-free survival in patients with acquired thrombotic thrombocytopenic purpura","year":2020,"lang":"en","type":"article","venue":"Hematology Transfusion and Cell Therapy","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital; University of Toronto","funders":"","keywords":"Medicine; Platelet; Complete remission; Internal medicine; Thrombotic thrombocytopenic purpura; Complete response; Gastroenterology; Surgery; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001577816,0.0003173569,0.0007045449,0.00009851214,0.0002360071,0.000032586,0.0001879365,0.0001654474,0.0006407013],"category_scores_gemma":[0.00001749452,0.0002230182,0.00002288588,0.000174595,0.0002687774,0.0001125227,0.0000736742,0.0001643982,0.00002035073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001733291,"about_ca_system_score_gemma":0.00006325202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000715523,"about_ca_topic_score_gemma":0.00009327546,"domain_scores_codex":[0.9982345,0.0003637332,0.0003476631,0.0006126967,0.00008151624,0.0003598763],"domain_scores_gemma":[0.9992505,0.0002186917,0.0001036831,0.0002598079,0.00005895742,0.0001083636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.04550606,0.000779513,0.1889099,0.0003953295,0.000317185,0.00005136163,0.007697948,0.000003656846,0.7480584,0.0001452346,0.001107394,0.007027997],"study_design_scores_gemma":[0.09603402,0.01793074,0.7337258,0.00122318,0.0001948478,0.0004301446,0.004456043,0.0001272495,0.1348751,0.0001763192,0.008511174,0.002315372],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953353,0.001885021,0.00003597752,0.001194354,0.00005692161,0.001206221,0.0001001783,0.0000505586,0.0001354379],"genre_scores_gemma":[0.9987557,0.0005978144,0.00008485938,0.0003252981,0.000004992495,0.00004423318,0.00007465287,0.00002519594,0.00008724492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6131833,"threshold_uncertainty_score":0.9094416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01749210028772109,"score_gpt":0.2201061889919774,"score_spread":0.2026140887042563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}