{"id":"W3094508323","doi":"10.1016/j.lfs.2020.118617","title":"Preventing the development of severe COVID-19 by modifying immunothrombosis","year":2020,"lang":"en","type":"review","venue":"Life Sciences","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Addiction and Mental Health; University of Toronto","funders":"Cancer Council Victoria; National Health and Medical Research Council; National Institutes of Health; Fernwood Foundation; Deakin University; Servier; Be Fit Foods; Novartis; University of Melbourne; Wilson Foundation; La Trobe University; University of Queensland; Meat and Livestock Australia; National Heart Foundation of Australia; Bond University; Simons Foundation Autism Research Initiative; Cancer Council Queensland; Bushfire Cooperative Research Centre; Pfizer Australia; Australian Research Council; PA Research Foundation; Australian Rotary Health; Multiple Sclerosis Australia; Sanofi; Beyond Blue","keywords":"ARDS; Proinflammatory cytokine; Immunology; Inflammation; Pyroptosis; Chemokine; Neutrophil extracellular traps; Alveolar macrophage; Medicine; Diffuse alveolar damage; Lung; Necroptosis; Cell biology; Macrophage; Biology; Acute respiratory distress; Apoptosis; Programmed cell death; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005798505,0.001056019,0.001674102,0.001169597,0.0001858284,0.0008684856,0.0008733419,0.001374853,0.002528759],"category_scores_gemma":[0.0007255483,0.000205673,0.0004767919,0.0008559402,0.0004636463,0.0006680545,0.000543694,0.00261423,0.001360002],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004190435,"about_ca_system_score_gemma":0.0005674628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007584113,"about_ca_topic_score_gemma":0.001368103,"domain_scores_codex":[0.9998521,0.00002382783,0.00002116483,0.00002823979,0.00005399436,0.00002059564],"domain_scores_gemma":[0.999781,0.0001040149,0.00003612515,0.00000857197,0.00004399717,0.00002634934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003127493,0.0001753279,0.0001398501,0.01136169,0.0001424241,0.0002049752,0.00002507848,0.0004065319,0.003155922,0.004258941,0.02668508,0.9531316],"study_design_scores_gemma":[0.0002043316,0.0004488959,0.001209058,0.004287951,0.0003384258,0.001535173,0.00003986579,0.0002266915,0.002164649,0.003600142,0.9859073,0.00003762876],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001675339,0.9986215,0.0002023926,0.0002544108,0.0002401036,0.000005838791,0.00002373517,0.00001130963,0.0004732405],"genre_scores_gemma":[0.001346834,0.9972509,0.0002943357,0.0003182461,0.0002167445,0.00001371935,0.00005193649,0.000002808199,0.0005044654],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002528759,"threshold_uncertainty_score":0.008459508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06390880268405956,"score_gpt":0.3509709633901547,"score_spread":0.2870621607060951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}