{"id":"W3094552190","doi":"10.1016/j.jtho.2020.10.007","title":"Outcomes According to ALK Status Determined by Central Immunohistochemistry or Fluorescence In Situ Hybridization in Patients With ALK-Positive NSCLC Enrolled in the Phase 3 ALEX Study","year":2020,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Takeda Canada; Merck Sharp and Dohme; Boehringer Ingelheim; Daiichi Sankyo Company; Clovis Oncology; F. Hoffmann-La Roche; Roche; Novartis; Merck; Pfizer; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Fluorescence in situ hybridization; Immunohistochemistry; In situ hybridization; In situ; Pathology; Internal medicine; Oncology; Gene; Genetics; Biology; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002119044,0.0001456132,0.0005051739,0.0001418129,0.00003579028,0.00001635152,0.0001302912,0.00004937657,0.00001440007],"category_scores_gemma":[0.0002819435,0.00008550542,0.00004408253,0.0004105142,0.00002604831,0.0001410917,0.00002604722,0.0002968205,0.000001021549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009316013,"about_ca_system_score_gemma":0.0005235555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007242043,"about_ca_topic_score_gemma":0.00009917979,"domain_scores_codex":[0.9985383,0.0001879519,0.0005581863,0.0001735305,0.0002726147,0.0002694786],"domain_scores_gemma":[0.999161,0.0001637313,0.0003055228,0.0001063033,0.0001238568,0.0001396047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02133161,0.004598006,0.9100204,0.00002538253,0.0001556434,0.001202476,0.01575809,0.0000825186,0.007226864,2.052699e-7,0.0001861737,0.0394127],"study_design_scores_gemma":[0.02988934,0.01178579,0.9434143,0.0002224955,0.0003430769,0.00004541131,0.01231223,0.00006553278,0.001601821,0.00000178981,0.0001691512,0.0001490464],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962497,0.00005983432,0.00008959571,0.002253662,0.00008446862,0.001055787,0.00001580699,0.000004130517,0.0001870336],"genre_scores_gemma":[0.9983369,0.000010338,0.0006795315,0.0008350594,0.0000383158,0.00003293396,0.00002683853,0.00001230271,0.00002780984],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03926365,"threshold_uncertainty_score":0.348681,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0144388878386544,"score_gpt":0.4180251668154065,"score_spread":0.4035862789767521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}