{"id":"W3094555446","doi":"10.3389/fimmu.2020.578505","title":"Preparing for Life: Plasma Proteome Changes and Immune System Development During the First Week of Human Life","year":2020,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; Prevention of Organ Failure; BC Children's Hospital; Simon Fraser University; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Medical Research Council; National Health and Medical Research Council; Natural Sciences and Engineering Research Council of Canada; A.P. Møller og Hustru Chastine Mc-Kinney Møllers Fond til almene Formaal; Killam Trusts; National Institutes of Health; H. Lundbeck A/S; Lundbeckfonden; Michael Smith Health Research BC; UK Research and Innovation; Medical Research Charities Group","keywords":"Proteome; Immune system; Human plasma; Human life; Immunology; Medicine; Computational biology; Biology; Bioinformatics; Chemistry; Political science; Chromatography","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001196653,0.0001198352,0.0002428071,0.00003795559,0.0001398707,0.00001110829,0.0001975496,0.0001360892,9.050075e-7],"category_scores_gemma":[0.0001044421,0.000104377,0.00003963403,0.00006635898,0.0000958543,0.000002948621,0.0001721124,0.00007773991,3.94855e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002134345,"about_ca_system_score_gemma":0.00004825721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001305743,"about_ca_topic_score_gemma":0.00003934424,"domain_scores_codex":[0.9992068,0.00003121593,0.0002433359,0.0002299647,0.00004521626,0.0002434996],"domain_scores_gemma":[0.9996506,0.000008212859,0.0001440856,0.000135783,0.00002738669,0.00003394653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001442029,0.0002587914,0.1156905,0.002283087,0.002471085,0.000002862564,0.005586286,0.0002476959,0.8599495,0.0003285023,0.00378244,0.007957178],"study_design_scores_gemma":[0.008617795,0.001865776,0.09572126,0.000304354,0.00009248914,0.000004697417,0.01371989,0.0008478565,0.8069881,0.00004415983,0.07094604,0.0008475533],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921734,0.006197233,0.000221176,0.0005735395,0.0001810908,0.0005060947,0.000008792985,0.00001321552,0.0001254053],"genre_scores_gemma":[0.9987811,0.0001159923,0.0006815017,0.00007600938,0.00004353794,0.0002014058,0.00002572717,0.00001773725,0.00005695794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06716359,"threshold_uncertainty_score":0.425637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006985202792108109,"score_gpt":0.1921710613061788,"score_spread":0.1851858585140707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}