{"id":"W3094555446","doi":"10.3389/fimmu.2020.578505","title":"Preparing for Life: Plasma Proteome Changes and Immune System Development During the First Week of Human Life","year":2020,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; Prevention of Organ Failure; BC Children's Hospital; Simon Fraser University; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Medical Research Council; National Health and Medical Research Council; Natural Sciences and Engineering Research Council of Canada; A.P. Møller og Hustru Chastine Mc-Kinney Møllers Fond til almene Formaal; Killam Trusts; National Institutes of Health; H. Lundbeck A/S; Lundbeckfonden; Michael Smith Health Research BC; UK Research and Innovation; Medical Research Charities Group","keywords":"Proteome; Immune system; Human plasma; Human life; Immunology; Medicine; Computational biology; Biology; Bioinformatics; Chemistry; Political science; Chromatography","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001930231,0.000254434,0.0002627817,0.0003851017,0.0002309117,0.0004705635,0.0001523723,0.0003149147,0.001411612],"category_scores_gemma":[0.0003292842,0.00008602584,0.000165559,0.0002995901,0.0001978849,0.0002373844,0.0002675527,0.0004111663,0.0003517928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001511867,"about_ca_system_score_gemma":0.0001505299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005048342,"about_ca_topic_score_gemma":0.000383298,"domain_scores_codex":[0.9998904,0.00001495183,0.000005640607,0.00004052521,0.00002768562,0.00002084871],"domain_scores_gemma":[0.9999106,0.00001385566,0.0000276494,0.000007533887,0.00001968476,0.00002069778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007299449,0.00003938208,0.04738021,0.0002415583,0.00005302628,0.00067247,0.0003984963,0.00005506803,0.9250429,0.0001306865,0.000311352,0.02494502],"study_design_scores_gemma":[0.000006464279,0.0006637453,0.8601517,0.00004714042,0.00006626647,0.002686535,0.0004877775,0.000221534,0.1297223,0.0003132113,0.005613503,0.00001983708],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990276,0.005702245,0.001565628,0.000128778,0.00002849797,0.00001590359,0.001074273,0.00003173242,0.001176927],"genre_scores_gemma":[0.9910139,0.003427188,0.002168638,0.0002070455,0.00002937174,0.00005108205,0.001270245,0.00002007193,0.001812326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001411612,"threshold_uncertainty_score":0.004722357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006985202792108109,"score_gpt":0.1921710613061788,"score_spread":0.1851858585140707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}