{"id":"W3094558991","doi":"10.1093/narcan/zcaa029","title":"Activation-induced cytidine deaminase localizes to G-quadruplex motifs at mutation hotspots in lymphoma","year":2020,"lang":"en","type":"article","venue":"NAR Cancer","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"National Institutes of Health; National Institute of General Medical Sciences; Cancer Research UK","keywords":"Cytidine deaminase; Somatic hypermutation; Biology; Genome instability; Cancer research; Lymphoma; Diffuse large B-cell lymphoma; Activation-induced (cytidine) deaminase; BCL6; Mantle cell lymphoma; Mutation; Gene; B cell; Molecular biology; Genetics; Antibody; DNA; DNA damage; Germinal center; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008711643,0.0001248655,0.00009911406,0.0006148733,0.0001514866,0.0001870647,0.0001017344,0.0001790466,0.001630865],"category_scores_gemma":[0.0001359218,0.0001227903,0.00008464089,0.000173657,0.0001447083,0.00008107572,0.0002189332,0.0001473009,0.0003558665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002360739,"about_ca_system_score_gemma":0.0000871815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004123955,"about_ca_topic_score_gemma":0.0006679021,"domain_scores_codex":[0.999921,0.00001429972,0.000004951938,0.00002249085,0.00001997295,0.00001714995],"domain_scores_gemma":[0.9999055,0.00001969869,0.0000293595,0.000009457667,0.00001474081,0.0000213041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009964744,0.000009548648,0.005767171,0.00002707803,0.00001239253,0.0001241021,0.00002534696,0.00006160665,0.9916956,0.00006985632,0.00005521674,0.002052438],"study_design_scores_gemma":[0.00008119016,0.0004683945,0.2655737,0.00001951679,0.00008451777,0.004828082,0.0001977083,0.002382259,0.7187874,0.0005817245,0.006982869,0.0000126887],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973641,0.0006347244,0.00116437,0.00002533262,0.000003939812,0.000008985815,0.000107718,0.00004870327,0.000642173],"genre_scores_gemma":[0.9986199,0.0001230809,0.0005858577,0.0000199834,0.000002638201,0.000007175724,0.000171812,0.000004933153,0.0004646146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001630865,"threshold_uncertainty_score":0.005455792,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06563281514068386,"score_gpt":0.3561076599280575,"score_spread":0.2904748447873737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}