{"id":"W3094566520","doi":"10.1038/s42255-020-00288-1","title":"Mitochondrial pyruvate carriers are required for myocardial stress adaptation","year":2020,"lang":"en","type":"article","venue":"Nature Metabolism","topic":"Diet and metabolism studies","field":"Medicine","cited_by":143,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; American Diabetes Association; American Heart Association; National Institutes of Health; Fondation Institut de Cardiologie de Montréal; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Foundation for the National Institutes of Health","keywords":"Glycolysis; Internal medicine; Mitochondrion; Endocrinology; Beta oxidation; Citric acid cycle; Biology; Pressure overload; Glycogen; Metabolism; Chemistry; Biochemistry; Muscle hypertrophy; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004707773,0.0004239674,0.0003602033,0.0002767599,0.00027188,0.0006557195,0.000378141,0.0006084649,0.002590657],"category_scores_gemma":[0.0005875945,0.0002602289,0.0002686447,0.0002356929,0.0005893178,0.0007971761,0.0005327315,0.0008178097,0.0002727508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003768688,"about_ca_system_score_gemma":0.0002074137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006745539,"about_ca_topic_score_gemma":0.000556556,"domain_scores_codex":[0.9998637,0.00003193763,0.00001435745,0.00003753757,0.00002079133,0.00003177279],"domain_scores_gemma":[0.9996613,0.00009863812,0.0000706904,0.00004874404,0.00004168575,0.00007889477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006732777,0.0001060646,0.002281187,0.0001223205,0.00004914848,0.0002631623,0.00008811193,0.0001030081,0.9849662,0.001035198,0.000191024,0.004061788],"study_design_scores_gemma":[0.0003512899,0.001495374,0.08290871,0.00003923325,0.0001603223,0.0008348391,0.0004219823,0.001645911,0.9046082,0.001964506,0.005540167,0.00002943576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900524,0.003351433,0.003291631,0.00101629,0.0002077051,0.00003061375,0.000316187,0.00003794076,0.001695792],"genre_scores_gemma":[0.9948035,0.00118938,0.001409758,0.0001809802,0.00004272871,0.00002175148,0.000426953,0.00002288861,0.001902024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002590657,"threshold_uncertainty_score":0.008666635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02436487065920473,"score_gpt":0.2802833302893314,"score_spread":0.2559184596301267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}