{"id":"W3094632508","doi":"10.1158/1535-7163.mct-20-0259","title":"Reprogramming of Nucleotide Metabolism Mediates Synergy between Epigenetic Therapy and MAP Kinase Inhibition","year":2020,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Occupational Cancer Research Centre; McGill University Health Centre; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Reprogramming; Biology; Epigenetics; Cancer research; Kinase; BET inhibitor; Cancer; MEK inhibitor; Genetics; Bioinformatics; MAPK/ERK pathway; Cell; Gene; Bromodomain","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001014489,0.000192665,0.0002088383,0.0001575603,0.0000862973,0.0002469417,0.0001209878,0.000130706,0.001975648],"category_scores_gemma":[0.00008723406,0.00006626526,0.0001612027,0.00009890796,0.0001261078,0.0001123704,0.0001751046,0.0002942106,0.0002133889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001738658,"about_ca_system_score_gemma":0.0001751156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001989679,"about_ca_topic_score_gemma":0.000773323,"domain_scores_codex":[0.9999439,0.00000947428,0.000003877135,0.000009615276,0.00001469601,0.00001848387],"domain_scores_gemma":[0.9999682,0.000007905061,0.000008609299,0.00000385075,0.000002983858,0.000008452133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005096177,0.0001665869,0.0005570335,0.00007068455,0.00001943913,0.00008843342,0.00001078711,0.0003547546,0.9864607,0.0003157658,0.0001797826,0.01126651],"study_design_scores_gemma":[0.00008720886,0.002260985,0.006786981,0.00001009094,0.00003685735,0.0003728906,0.00003284924,0.002375556,0.9826089,0.0001665145,0.005255437,0.000005670198],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918929,0.002028019,0.001891668,0.0001322889,0.0000562916,0.00005860718,0.0002606474,0.00005992896,0.003619523],"genre_scores_gemma":[0.9980727,0.00044336,0.0003906066,0.00002346366,0.000005986191,0.0000161206,0.0001176455,0.000003600973,0.0009264532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001975648,"threshold_uncertainty_score":0.006609201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02891240839028595,"score_gpt":0.2730069190894758,"score_spread":0.2440945106991898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}