{"id":"W3094639421","doi":"10.1101/2020.11.01.364299","title":"Orai1- and Orai2-, but not Orai3-mediated I <sub>CRAC</sub> is regulated by intracellular pH","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"York University; Australian Research Council; University of Connecticut","keywords":"ORAI1; STIM1; Intracellular; Cell biology; Chemistry; Gene isoform; HEK 293 cells; Biophysics; Biochemistry; Biology; Gene; Endoplasmic reticulum","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000137468,0.0002499777,0.0002825163,0.0001179366,0.00009744946,0.0003269459,0.0002171722,0.0001855943,0.002171158],"category_scores_gemma":[0.000188423,0.00009445847,0.0004602809,0.0001257394,0.0002631357,0.0002268642,0.0002387756,0.0003958047,0.0005679931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003368837,"about_ca_system_score_gemma":0.0001632681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008017608,"about_ca_topic_score_gemma":0.0007027896,"domain_scores_codex":[0.9998312,0.0000156447,0.00001272659,0.00002858233,0.00003730378,0.00007443602],"domain_scores_gemma":[0.9998149,0.00002587802,0.00005976969,0.00002619092,0.00003085518,0.00004242915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001884292,0.00001049075,0.0001980184,0.00003372242,0.000005060513,0.00003278898,0.000009960593,0.00001900957,0.9991159,0.00003718122,0.00003510217,0.0003143547],"study_design_scores_gemma":[0.00002556356,0.0001400607,0.02064,0.00001179617,0.0000228716,0.0003109389,0.00005210955,0.001281288,0.976054,0.00003688314,0.001418517,0.000005871119],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938987,0.001487644,0.001678007,0.000085,0.00003076747,0.00002614682,0.0004985096,0.0001074954,0.002187653],"genre_scores_gemma":[0.9969799,0.0005263786,0.0006334382,0.00006276896,0.00001100652,0.00002670183,0.0004453469,0.00003554054,0.001278845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002171158,"threshold_uncertainty_score":0.007263243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01861816510764713,"score_gpt":0.2087824685624937,"score_spread":0.1901643034548466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}