{"id":"W3094679970","doi":"10.1182/blood-2020-137650","title":"Cite-Seq Profiling of T Cells in Multiple Myeloma Patients Undergoing BCMA Targeting CAR-T or Bites Immunotherapy","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Calgary","funders":"","keywords":"Bone marrow; T cell; Immunology; CD8; Immune system; Immunotherapy; Antigen; Peripheral blood mononuclear cell; Cell therapy; Medicine; CD19; Biology; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001543347,0.0001816215,0.0005477711,0.0004043762,0.0002412491,0.0005058805,0.0001455186,0.0003841904,0.001323048],"category_scores_gemma":[0.0003099331,0.0001083195,0.0002875775,0.0005843348,0.0001813116,0.000109521,0.0002537944,0.0004548142,0.0003655654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001347024,"about_ca_system_score_gemma":0.0001408578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007094344,"about_ca_topic_score_gemma":0.001386797,"domain_scores_codex":[0.9998224,0.00001557536,0.00001141471,0.00006697564,0.00004363212,0.00003991529],"domain_scores_gemma":[0.9998127,0.00005196257,0.00004251051,0.00001324452,0.00004943562,0.00003011524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00196223,0.0000971636,0.1045777,0.0003863433,0.0001625802,0.0005878098,0.0006593899,0.001214221,0.8638343,0.0001299966,0.001403867,0.02498436],"study_design_scores_gemma":[0.00004374874,0.000877178,0.8516246,0.00007350036,0.0003732834,0.002269949,0.001641598,0.006749431,0.1235714,0.0003910194,0.01233174,0.00005258939],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841398,0.001181695,0.00288635,0.00009848709,0.00003333818,0.00003865666,0.010555,0.00008163045,0.0009851214],"genre_scores_gemma":[0.9762666,0.0008790367,0.004630974,0.0004053259,0.00005481317,0.0001759483,0.0149964,0.00005877864,0.002532053],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001323048,"threshold_uncertainty_score":0.004426003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03061909408862479,"score_gpt":0.2762528351811011,"score_spread":0.2456337410924763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}