{"id":"W3094714150","doi":"10.1182/blood-2020-136135","title":"Molecular Response Patterns in Hydroxyurea (HU)-Resistant or Intolerant Polycythemia Vera (PV) during Treatment with Idasanutlin: Results of an Open-Label, Single-Arm Phase 2 Study","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Polycythemia vera; Medicine; Open label; Internal medicine; Gastroenterology; Immunology; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001205765,0.0004515064,0.001185584,0.0002997872,0.00017489,0.0006342101,0.0003208141,0.0004948121,0.001248251],"category_scores_gemma":[0.0008976741,0.0002252193,0.0007318907,0.0003372559,0.0003570372,0.0004613047,0.0001966149,0.001041587,0.0002411847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003992405,"about_ca_system_score_gemma":0.0003123659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002367285,"about_ca_topic_score_gemma":0.0005358722,"domain_scores_codex":[0.9994982,0.0002194935,0.00004170376,0.0001126416,0.00006739995,0.00006047808],"domain_scores_gemma":[0.9992599,0.0001810033,0.0002158858,0.00005328612,0.00004863579,0.0002414023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6274921,0.03846541,0.09917881,0.001138336,0.003818656,0.0004617686,0.000456942,0.002464889,0.08849961,0.0001727217,0.001818763,0.136032],"study_design_scores_gemma":[0.1324619,0.5747645,0.2773258,0.00007384633,0.001973692,0.0008323828,0.0001566382,0.002206354,0.006432395,0.000267464,0.00343297,0.00007204831],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974756,0.001201328,0.000162295,0.00003459869,0.00001844799,0.0003898312,0.0003517798,0.00001272599,0.0003535467],"genre_scores_gemma":[0.9978089,0.0004416714,0.0003118448,0.0001361026,0.00004709145,0.0003251886,0.0006272167,0.000005384733,0.0002965454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001248251,"threshold_uncertainty_score":0.006376803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05130384645611689,"score_gpt":0.3253553041844848,"score_spread":0.2740514577283679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}