{"id":"W3094715636","doi":"10.1038/s41467-020-19113-0","title":"CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Core Research for Evolutional Science and Technology; University of Tokyo; ZonMw; National Institute of Diabetes and Digestive and Kidney Diseases; Japan Society for the Promotion of Science; National Institutes of Health; Tokyo University of Agriculture and Technology; Deutsche Forschungsgemeinschaft; Max-Planck-Gesellschaft; Tokyo University of Agriculture; Japan Science and Technology Corporation; European Commission","keywords":"Dynein; Cilium; Flagellum; Biology; Cell biology; Intraflagellar transport; Microtubule; Ciliopathy; Adenosine triphosphate; ATPase; Axoneme; Dynein ATPase; Adenosine diphosphate; Adenylate kinase; Biochemistry; Phenotype; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006666145,0.0001554858,0.0001302467,0.00002148999,0.000319418,0.00005918586,0.0005862266,0.0001757705,0.00001591084],"category_scores_gemma":[0.0002204285,0.0001527289,0.00005157487,0.0001112501,0.000197284,0.00001289029,0.0004246796,0.0002542559,0.000005316839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006283753,"about_ca_system_score_gemma":0.00005777186,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002397761,"about_ca_topic_score_gemma":0.00007366316,"domain_scores_codex":[0.9991341,0.0001025854,0.0001780016,0.0002817719,0.000100961,0.0002026286],"domain_scores_gemma":[0.9987506,0.00002581311,0.0000681247,0.0008200863,0.00008829264,0.000247082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002044349,0.001086502,0.06736971,0.0001753954,0.0002241783,0.000006598242,0.003045804,0.0001158801,0.8563831,0.003305849,0.05979058,0.008291962],"study_design_scores_gemma":[0.003762532,0.001922099,0.1855117,0.00009584962,0.0005517635,0.000119297,0.01183337,0.003105816,0.1374464,0.0003367821,0.6527213,0.002593034],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9458579,0.0486205,0.0001504656,0.003825204,0.00003133735,0.000156239,0.0003802688,0.00004239471,0.0009356696],"genre_scores_gemma":[0.9923327,0.002193101,0.002815689,0.001680432,0.00007602519,0.00001987346,0.0007778216,0.00002356503,0.00008080794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7189367,"threshold_uncertainty_score":0.6228104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01549407872519048,"score_gpt":0.2746820947554137,"score_spread":0.2591880160302232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}