{"id":"W3094715636","doi":"10.1038/s41467-020-19113-0","title":"CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Core Research for Evolutional Science and Technology; University of Tokyo; ZonMw; National Institute of Diabetes and Digestive and Kidney Diseases; Japan Society for the Promotion of Science; National Institutes of Health; Tokyo University of Agriculture and Technology; Deutsche Forschungsgemeinschaft; Max-Planck-Gesellschaft; Tokyo University of Agriculture; Japan Science and Technology Corporation; European Commission","keywords":"Dynein; Cilium; Flagellum; Biology; Cell biology; Intraflagellar transport; Microtubule; Ciliopathy; Adenosine triphosphate; ATPase; Axoneme; Dynein ATPase; Adenosine diphosphate; Adenylate kinase; Biochemistry; Phenotype; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001285134,0.0007245002,0.0002268629,0.0007085413,0.0002117446,0.0002880816,0.000205097,0.0005949683,0.001740589],"category_scores_gemma":[0.0001902587,0.0002133307,0.0003948168,0.0002079275,0.0005592758,0.0001918616,0.0003979528,0.0004010685,0.0003120968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002415925,"about_ca_system_score_gemma":0.0002551737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001087971,"about_ca_topic_score_gemma":0.001328819,"domain_scores_codex":[0.999816,0.00002260311,0.00003183855,0.00005230979,0.00005339745,0.00002391288],"domain_scores_gemma":[0.9997082,0.00003314568,0.0001244728,0.0000169652,0.00001432977,0.0001029232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009058962,0.00001629902,0.001813349,0.00005081167,0.00002108536,0.002163096,0.00002226573,0.0001005402,0.9942326,0.0002257393,0.00006532678,0.001198245],"study_design_scores_gemma":[0.00005824249,0.0004515965,0.08455112,0.00005249831,0.0001347,0.03253509,0.0001369722,0.002705288,0.8741751,0.0004600469,0.004717462,0.00002184191],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943342,0.0005912083,0.003247902,0.0001300253,0.00003699404,0.00001786949,0.0005964573,0.0001977345,0.0008475533],"genre_scores_gemma":[0.9974118,0.0002302231,0.001164765,0.00003698615,0.000007409034,0.000007196549,0.0002414691,0.00001990581,0.0008803033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001740589,"threshold_uncertainty_score":0.005822778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01549407872519048,"score_gpt":0.2746820947554137,"score_spread":0.2591880160302232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}