{"id":"W3094720086","doi":"10.1093/neuonc/noaa251","title":"A subset of pediatric-type thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of <i>EGFR</i>","year":2020,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Brain Tumour Charity; Cancer Research UK","keywords":"Missense mutation; Epidermal growth factor receptor; Biology; Cancer research; Glioma; DNA methylation; Methylation; Mutation; Pathology; Gene; Genetics; Medicine; Cancer; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001149181,0.0003265454,0.0002737754,0.0005798211,0.0001944184,0.0003296722,0.0002115815,0.0001514392,0.001019067],"category_scores_gemma":[0.0004158528,0.0001104568,0.0001827755,0.0004856965,0.0002031715,0.0001549352,0.0002744149,0.0001572937,0.0002838471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002160302,"about_ca_system_score_gemma":0.0002485889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008683702,"about_ca_topic_score_gemma":0.001979319,"domain_scores_codex":[0.9998665,0.00001046883,0.00001409472,0.00003738387,0.00003823677,0.00003327376],"domain_scores_gemma":[0.9996001,0.00003578348,0.0002380049,0.00003163394,0.0000424674,0.00005205056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003818428,0.00003062286,0.8173851,0.0001527909,0.00009013213,0.006054574,0.0003764711,0.0002354456,0.1531096,0.0002494452,0.0003766813,0.02155718],"study_design_scores_gemma":[0.00001029906,0.0002021094,0.9123651,0.00001239881,0.00007243017,0.06248308,0.0003490506,0.0003761627,0.02213245,0.0001856431,0.001802665,0.000008653066],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980331,0.0002839037,0.0008599107,0.00001381791,0.000001714517,0.00001088854,0.0003369616,0.00002584343,0.0004338767],"genre_scores_gemma":[0.9977241,0.0003275147,0.0008074889,0.00001588517,0.000006387549,0.0000176263,0.0009557724,0.00001252684,0.0001326181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001019067,"threshold_uncertainty_score":0.003409088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03256884881697442,"score_gpt":0.2987284875695571,"score_spread":0.2661596387525826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}