{"id":"W3094810190","doi":"10.1182/blood-2020-140895","title":"Variation in Stem Cell Driven Hierarchies Underlies Clinical Outcome and Drug Response in AML","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Princess Margaret Cancer Centre; University of Toronto; Health Sciences Centre; University Health Network","funders":"","keywords":"Stem cell; Biology; Progenitor cell; Population; Myeloid leukemia; Leukemia; Immunology; Cancer stem cell; Oncology; Cancer research; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005567205,0.0001351435,0.0003640557,0.0005202678,0.0001782461,0.0005546866,0.0001928155,0.0002693882,0.001308846],"category_scores_gemma":[0.001510684,0.0001410172,0.0002115257,0.0004439559,0.0002725394,0.0002189023,0.0004419471,0.0005778799,0.0003036321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000290048,"about_ca_system_score_gemma":0.0001721078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008373445,"about_ca_topic_score_gemma":0.001126021,"domain_scores_codex":[0.9996415,0.00005476198,0.00003077085,0.0001255789,0.00008263248,0.00006474217],"domain_scores_gemma":[0.999386,0.0001819292,0.0002139884,0.00007290036,0.00004659567,0.00009863183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001546449,0.00009212184,0.8392031,0.00005625487,0.0002556064,0.0002315223,0.0004241174,0.001847526,0.12963,0.0003907686,0.0007189096,0.02560369],"study_design_scores_gemma":[0.00001958246,0.0001472634,0.9885318,0.000006512025,0.00005191451,0.0003089328,0.0001190883,0.00296138,0.006446623,0.0006624344,0.0007308657,0.00001360577],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998363,0.0002518367,0.0005387055,0.00004509304,0.000002524975,0.000008031933,0.0004356587,0.00002149246,0.0003337124],"genre_scores_gemma":[0.9992129,0.00004651129,0.000165819,0.00003932434,0.000002854087,0.00000690661,0.0003947552,0.00001059271,0.0001203484],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001308846,"threshold_uncertainty_score":0.004378557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05312269468960214,"score_gpt":0.3386781360173143,"score_spread":0.2855554413277122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}