{"id":"W3094811716","doi":"10.1186/s40478-020-01038-w","title":"Genetic predisposition to longer telomere length and risk of childhood, adolescent and adult-onset ependymoma","year":2020,"lang":"en","type":"article","venue":"Acta Neuropathologica Communications","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"Duke Cancer Institute; National Center for Chronic Disease Prevention and Health Promotion; National Institute of General Medical Sciences; National Cancer Institute; Perelman School of Medicine, University of Pennsylvania; School of Medicine, Duke University; National Institutes of Health; University of Southern California; Cancer Registry of Greater California; Hospital for Sick Children; Centers for Disease Control and Prevention; University of Pennsylvania; University of California, San Francisco; Children's Hospital of Philadelphia; Sontag Foundation; Pediatric Brain Tumor Foundation; California Department of Public Health; Cancer Prevention and Research Institute of Texas; Alex's Lemonade Stand Foundation for Childhood Cancer","keywords":"Ependymoma; Telomere; Medicine; Neurology; Genetic predisposition; Neuroscience; Pediatrics; Psychology; Genetics; Psychiatry; Internal medicine; Pathology; Biology; Disease; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001183199,0.0002006624,0.0003479776,0.00009348285,0.0002379838,0.00002425152,0.0003704957,0.00008330268,0.00002016087],"category_scores_gemma":[0.0008226851,0.000173264,0.00005775801,0.0003150032,0.000300282,0.00007360765,0.0005164518,0.0004131145,0.00001338146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001110783,"about_ca_system_score_gemma":0.00003315276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002004051,"about_ca_topic_score_gemma":0.00001216255,"domain_scores_codex":[0.9984719,0.0003612586,0.0003846988,0.0003978273,0.0001735859,0.0002107482],"domain_scores_gemma":[0.9980226,0.0001957341,0.000169252,0.001136619,0.0001455213,0.0003302424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004231298,0.001260593,0.8729515,0.0002486389,0.00008997957,0.0001841203,0.007175711,0.000005803462,0.0630967,0.0002237937,0.001491202,0.05284882],"study_design_scores_gemma":[0.0005959372,0.0007031849,0.9953951,0.00008291379,0.0001845912,0.0004764307,0.0003105951,0.0002667311,0.0009129895,0.00002694187,0.0008829368,0.0001616471],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892163,0.001240821,0.00009265034,0.008222103,0.00002062115,0.0006598376,0.0001434522,0.00009897864,0.0003052606],"genre_scores_gemma":[0.9805684,0.01029578,0.006406184,0.002584353,0.00003721673,0.00003408146,0.00003835914,0.00002487856,0.00001074593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1224436,"threshold_uncertainty_score":0.7065502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02246254401929473,"score_gpt":0.2523520010875669,"score_spread":0.2298894570682722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}