{"id":"W3094811716","doi":"10.1186/s40478-020-01038-w","title":"Genetic predisposition to longer telomere length and risk of childhood, adolescent and adult-onset ependymoma","year":2020,"lang":"en","type":"article","venue":"Acta Neuropathologica Communications","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"Duke Cancer Institute; National Center for Chronic Disease Prevention and Health Promotion; National Institute of General Medical Sciences; National Cancer Institute; Perelman School of Medicine, University of Pennsylvania; School of Medicine, Duke University; National Institutes of Health; University of Southern California; Cancer Registry of Greater California; Hospital for Sick Children; Centers for Disease Control and Prevention; University of Pennsylvania; University of California, San Francisco; Children's Hospital of Philadelphia; Sontag Foundation; Pediatric Brain Tumor Foundation; California Department of Public Health; Cancer Prevention and Research Institute of Texas; Alex's Lemonade Stand Foundation for Childhood Cancer","keywords":"Ependymoma; Telomere; Medicine; Neurology; Genetic predisposition; Neuroscience; Pediatrics; Psychology; Genetics; Psychiatry; Internal medicine; Pathology; Biology; Disease; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005973857,0.0002620983,0.0002102552,0.0009409582,0.0002821895,0.0004896713,0.0002643253,0.000312516,0.00194158],"category_scores_gemma":[0.002181448,0.0001757275,0.0003623155,0.0009711069,0.0002338694,0.000179466,0.0002965341,0.0003293435,0.0001178586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002227071,"about_ca_system_score_gemma":0.0001771725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007145133,"about_ca_topic_score_gemma":0.005141311,"domain_scores_codex":[0.9996061,0.00008058851,0.00004862722,0.0001609657,0.00005829292,0.00004546556],"domain_scores_gemma":[0.9978992,0.0004454833,0.001081914,0.0001969399,0.0001628256,0.0002136005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001552428,0.00001148097,0.9980376,0.000007886228,0.000103253,0.0001327886,0.00004991936,0.00004693436,0.0006375113,0.00002334209,0.00005656168,0.0007374667],"study_design_scores_gemma":[0.000006556423,0.00004668801,0.9989962,0.000005971388,0.00005210411,0.0004013769,0.00005289431,0.0001009244,0.0001605786,0.00002292503,0.0001517137,0.000002058728],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988686,0.0002378443,0.000154438,0.00001642219,0.000003209351,0.000004208482,0.0004345265,0.000004652606,0.0002761014],"genre_scores_gemma":[0.9992979,0.00008156831,0.0001358524,0.000008910984,0.000004460553,0.000005056402,0.0003744499,0.000002471906,0.00008932089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007145133,"threshold_uncertainty_score":0.01420707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02246254401929473,"score_gpt":0.2523520010875669,"score_spread":0.2298894570682722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}