{"id":"W3094825391","doi":"10.1016/j.molimm.2020.10.013","title":"Fish complement C8 evolution, functional network analyses, and the theoretical interaction between C8 alpha chain and CD59","year":2020,"lang":"en","type":"article","venue":"Molecular Immunology","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ministry of Agriculture","funders":"Agriculture Research System of China; Shanghai Engineering Technology Research Center","keywords":"Biology; Gene; Grass carp; Genetics; Zebrafish; Complement system; Phylogenetic tree; Computational biology; Fish <Actinopterygii>; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003907704,0.0002594839,0.0001813507,0.0007590302,0.0005825804,0.0005389716,0.0005803505,0.0004195583,0.003374816],"category_scores_gemma":[0.001483144,0.0001334925,0.0003076114,0.0004960471,0.000625968,0.0008947359,0.0003893874,0.0003679838,0.0002072059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001434338,"about_ca_system_score_gemma":0.0004267992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004393515,"about_ca_topic_score_gemma":0.003073164,"domain_scores_codex":[0.999903,0.00002699971,0.000003295561,0.00002893007,0.00001691935,0.00002079665],"domain_scores_gemma":[0.9997259,0.0001136343,0.00005438811,0.00002624337,0.00004252957,0.00003738528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0005792686,0.0001119779,0.0920115,0.000239694,0.0002076255,0.0009519429,0.0006154681,0.2086108,0.1498672,0.493415,0.001494504,0.05189495],"study_design_scores_gemma":[0.00002468351,0.0001049532,0.04568221,0.00002793383,0.000107482,0.0006058487,0.000409695,0.7092482,0.01365203,0.225613,0.004487288,0.00003666758],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9661144,0.0003019206,0.02374221,0.0006010063,0.00001292761,0.00000855788,0.0001149786,0.00004218121,0.009061832],"genre_scores_gemma":[0.9964018,0.0001329605,0.002567718,0.00001931808,0.000005480826,0.000004869733,0.00004721666,0.000005965965,0.0008147659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004393515,"threshold_uncertainty_score":0.01128989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02701075340583424,"score_gpt":0.2748000967420716,"score_spread":0.2477893433362373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}