{"id":"W3094825391","doi":"10.1016/j.molimm.2020.10.013","title":"Fish complement C8 evolution, functional network analyses, and the theoretical interaction between C8 alpha chain and CD59","year":2020,"lang":"en","type":"article","venue":"Molecular Immunology","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ministry of Agriculture","funders":"Agriculture Research System of China; Shanghai Engineering Technology Research Center","keywords":"Biology; Gene; Grass carp; Genetics; Zebrafish; Complement system; Phylogenetic tree; Computational biology; Fish <Actinopterygii>; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003450255,0.0002258217,0.0004228202,0.00006001348,0.0003440291,0.00003199565,0.0002008203,0.0001416707,0.001097057],"category_scores_gemma":[0.0001747569,0.0001748537,0.0001096294,0.0001574469,0.001149508,0.00005061862,0.0004077856,0.0003238657,0.00007091619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000488512,"about_ca_system_score_gemma":0.00003203842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000766082,"about_ca_topic_score_gemma":0.00001297282,"domain_scores_codex":[0.997582,0.001107415,0.0004444316,0.0004226894,0.00006143844,0.0003820767],"domain_scores_gemma":[0.9990157,0.0004325506,0.0001578366,0.0002804427,0.00007326117,0.00004013162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"observational","study_design_scores_codex":[0.003833058,0.0001808862,0.04489679,0.00008858386,0.007068058,0.00003825434,0.001232886,0.0002772095,0.1566817,0.7448359,0.03534997,0.005516722],"study_design_scores_gemma":[0.03311842,0.00218825,0.6655459,0.0002143379,0.00288911,0.0006504707,0.00448296,0.001368162,0.01712313,0.04729732,0.2232898,0.001832105],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9046414,0.02061964,0.04599669,0.02579342,0.0008783552,0.001131355,0.0001322956,0.0001649697,0.000641827],"genre_scores_gemma":[0.9976349,0.00005784557,0.00005417905,0.001633439,0.000111643,0.00007032317,0.0003920019,0.00001729728,0.00002839036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6975386,"threshold_uncertainty_score":0.9998161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02701075340583424,"score_gpt":0.2748000967420716,"score_spread":0.2477893433362373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}