{"id":"W3094845574","doi":"10.1182/blood-2020-133922","title":"Efficacy and Safety of Ponatinib (PON) in Patients with Chronic-Phase Chronic Myeloid Leukemia (CP-CML) Who Failed One or More Second-Generation (2G) Tyrosine Kinase Inhibitors (TKIs): Analyses Based on PACE and Optic","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Medicine; Ponatinib; Internal medicine; Clinical trial; Population; Interim analysis; Oncology; Myeloid leukemia; Dasatinib; Imatinib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003137003,0.0004515875,0.0009360228,0.0004313294,0.0001822927,0.0006802376,0.0005194217,0.000499777,0.0008466335],"category_scores_gemma":[0.003173972,0.0002141492,0.001650453,0.0005446722,0.0006008928,0.0008396327,0.0005468292,0.0009698176,0.0001226929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009915809,"about_ca_system_score_gemma":0.0008596134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004881018,"about_ca_topic_score_gemma":0.001150633,"domain_scores_codex":[0.9986749,0.0005768319,0.0001272095,0.0002268381,0.0002726263,0.0001216003],"domain_scores_gemma":[0.9973884,0.0008157142,0.001079611,0.0001907968,0.0001368091,0.0003886305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.463467,0.003951385,0.406281,0.0009904589,0.004779802,0.0002003335,0.0003018012,0.006012457,0.009986589,0.0004623772,0.001899904,0.1016669],"study_design_scores_gemma":[0.08359652,0.2225368,0.6677815,0.00009777658,0.004587216,0.0009598162,0.0001944562,0.006821524,0.005657726,0.0007665703,0.006899778,0.0001005095],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975936,0.0009523166,0.0001144967,0.00007702367,0.000009689346,0.0001427957,0.0004947847,0.0000067817,0.0006086938],"genre_scores_gemma":[0.9980509,0.0003381631,0.0002412931,0.0001030214,0.00003196421,0.000134528,0.0009430314,0.000002515374,0.0001545505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003137003,"threshold_uncertainty_score":0.0165903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02353885709393887,"score_gpt":0.2795732222064298,"score_spread":0.2560343651124909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}