{"id":"W3094910255","doi":"10.3390/v12111266","title":"JSRV Intragenic Enhancer Element Increases Expression from a Heterologous Promoter and Promotes High Level AAV-Mediated Transgene Expression in the Lung and Liver of Mice","year":2020,"lang":"en","type":"article","venue":"Viruses","topic":"Infectious Diseases and Mycology","field":"Veterinary","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada","keywords":"Transgene; Enhancer; Heterologous; Biology; Genetically modified mouse; Molecular biology; Heterologous expression; Gene expression; Virology; Gene; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001096929,0.0001872224,0.0002664449,0.00005360818,0.00007240122,0.00002397316,0.0001264,0.0001129951,0.0003501518],"category_scores_gemma":[0.00007794648,0.0001266082,0.0000403705,0.00008367688,0.00008986489,0.0001460246,0.0001139154,0.0001375607,0.000005569219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001370234,"about_ca_system_score_gemma":0.0000241237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001319657,"about_ca_topic_score_gemma":0.0001035446,"domain_scores_codex":[0.9986776,0.0003366222,0.0002877931,0.0003502156,0.000136036,0.0002117292],"domain_scores_gemma":[0.9993479,0.0002856159,0.0001103237,0.0001510926,0.00002600082,0.00007909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001264873,0.0002570604,0.008330171,0.0001439774,0.00004138709,0.00009238152,0.003762368,0.000001748808,0.9848205,0.000004511465,0.0004187101,0.0008622779],"study_design_scores_gemma":[0.003649187,0.002984039,0.2610151,0.0003130902,0.0001955184,0.00004922737,0.0004536817,0.000741795,0.7293425,0.0001627115,0.0006642373,0.000428927],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956751,0.002975624,0.0001345863,0.000148769,0.00003921302,0.0006264289,0.0003496481,0.00003845636,0.00001211469],"genre_scores_gemma":[0.9977655,0.0005559062,0.0002965999,0.001106421,0.00009265142,0.0001178661,0.00004379488,0.0000198429,0.000001349667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.255478,"threshold_uncertainty_score":0.5162933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04909895099207397,"score_gpt":0.2896471498410014,"score_spread":0.2405481988489274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}