{"id":"W3094910255","doi":"10.3390/v12111266","title":"JSRV Intragenic Enhancer Element Increases Expression from a Heterologous Promoter and Promotes High Level AAV-Mediated Transgene Expression in the Lung and Liver of Mice","year":2020,"lang":"en","type":"article","venue":"Viruses","topic":"Infectious Diseases and Mycology","field":"Veterinary","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada","keywords":"Transgene; Enhancer; Heterologous; Biology; Genetically modified mouse; Molecular biology; Heterologous expression; Gene expression; Virology; Gene; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002719505,0.0003428341,0.000198844,0.0003679715,0.00009761184,0.0003364108,0.0001856136,0.0002712205,0.001212949],"category_scores_gemma":[0.0001560926,0.0002026201,0.0002195618,0.0001145782,0.0002445823,0.0002052175,0.0002778526,0.0006871396,0.0004293322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001728486,"about_ca_system_score_gemma":0.0002016484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002004111,"about_ca_topic_score_gemma":0.000603998,"domain_scores_codex":[0.9997696,0.0000363853,0.00002217636,0.00006362732,0.00007041143,0.00003774715],"domain_scores_gemma":[0.9997757,0.00004356322,0.00007014671,0.0000269011,0.0000256899,0.00005795103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001405074,0.00001262042,0.00009660834,0.00001179153,0.000001947974,0.00001407465,0.000007754305,0.00002346356,0.9989792,0.00008265139,0.00001212188,0.0007437966],"study_design_scores_gemma":[0.00001061272,0.000252441,0.002869807,0.00001274486,0.00001809828,0.0002895062,0.00001675747,0.0008211822,0.9922553,0.00003992301,0.003409957,0.000003660239],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.972347,0.001444015,0.02220807,0.00009230821,0.00003748102,0.0000559647,0.0002409178,0.0004042063,0.003170081],"genre_scores_gemma":[0.974985,0.0009421968,0.01569157,0.0000425371,0.00001973503,0.00004443889,0.0005947159,0.0001057443,0.007573945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001212949,"threshold_uncertainty_score":0.004057765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04909895099207397,"score_gpt":0.2896471498410014,"score_spread":0.2405481988489274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}