{"id":"W3094984583","doi":"10.1007/s00213-020-05685-8","title":"Nicotine sensitization (part 1): estradiol or tamoxifen is required during the induction phase and not the expression phase to enable locomotor sensitization to nicotine in female rats","year":2020,"lang":"en","type":"article","venue":"Psychopharmacology","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Brock University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Nicotine; Sensitization; Agonist; Endocrinology; Internal medicine; Estrogen receptor; Pharmacology; Tamoxifen; Estrogen; Receptor; Medicine; Chemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003390527,0.0006537056,0.0006778406,0.0007284647,0.0004175235,0.0006380606,0.000616809,0.0007622343,0.003427734],"category_scores_gemma":[0.0006145451,0.0005733523,0.0009218969,0.000336935,0.001007609,0.001016133,0.0006274168,0.002066937,0.001106593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007463827,"about_ca_system_score_gemma":0.0008108786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001642983,"about_ca_topic_score_gemma":0.004406639,"domain_scores_codex":[0.9994661,0.00006199755,0.00005540724,0.0001528829,0.00009844822,0.0001652293],"domain_scores_gemma":[0.9987777,0.000256655,0.0004154534,0.0002114989,0.000085653,0.0002531112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009518472,0.0001323821,0.000490967,0.00002457395,0.000004984365,0.00008267568,0.00004245111,0.00002208749,0.9967515,0.0001268431,0.00005234484,0.001317252],"study_design_scores_gemma":[0.00006402861,0.001037662,0.01572125,0.0000161099,0.00003065413,0.0002553542,0.00007162922,0.0001667453,0.9806816,0.00007474846,0.001866835,0.00001333776],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904897,0.001214751,0.003856967,0.000325986,0.0001057381,0.000185933,0.001597834,0.0002310957,0.001991848],"genre_scores_gemma":[0.9742488,0.0009429764,0.003768255,0.0003782408,0.00005675008,0.000487153,0.002497854,0.0003692705,0.01725082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003427734,"threshold_uncertainty_score":0.01146692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0298991651469941,"score_gpt":0.3410591417816226,"score_spread":0.3111599766346285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}