{"id":"W3094988533","doi":"10.1038/s41598-020-75754-7","title":"Masking terminal neo-epitopes of linear peptides through glycosylation favours immune responses towards core epitopes producing parental protein bound antibodies","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"National Research Council Canada; Health Canada","keywords":"Epitope; Linear epitope; Antibody; Immunogenicity; Immunogen; Peptide; Glycosylation; Biology; Chemistry; Mimotope; Peptide sequence; Molecular biology; Biochemistry; Monoclonal antibody; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002029161,0.0003186535,0.0001675527,0.0001164244,0.00007140607,0.0002642996,0.0001875898,0.0002688979,0.0008115991],"category_scores_gemma":[0.0001563059,0.0001538978,0.000129694,0.0001162918,0.0001984804,0.0001704703,0.0001901033,0.0003923357,0.000296539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000153975,"about_ca_system_score_gemma":0.0001157375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001404849,"about_ca_topic_score_gemma":0.0002464163,"domain_scores_codex":[0.9998683,0.00002506495,0.000008872988,0.00002697717,0.00003732879,0.00003351835],"domain_scores_gemma":[0.9999105,0.0000221111,0.00002562497,0.00001394611,0.00001164107,0.00001619907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001667889,0.00001123809,0.00005383969,0.000008233153,8.625822e-7,0.0000114396,0.000004510401,0.00002369277,0.9994419,0.00004801703,0.000006878066,0.0003727601],"study_design_scores_gemma":[0.000007645894,0.0001690411,0.0006831535,0.000002078797,0.000004705524,0.0001261781,0.0000049806,0.000610623,0.9977897,0.00002613321,0.0005739753,0.000001731303],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910189,0.0002602345,0.007419549,0.00003804689,0.0000118058,0.0000299957,0.00003150982,0.00005858559,0.001131367],"genre_scores_gemma":[0.9924095,0.0002296972,0.006138416,0.00004192854,0.000006814601,0.00001445346,0.00006199546,0.00001855815,0.001078548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008115991,"threshold_uncertainty_score":0.002715111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07383761107489552,"score_gpt":0.3480652868040771,"score_spread":0.2742276757291816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}