{"id":"W3095000751","doi":"10.1182/blood-2020-136586","title":"Potency-Adjusted Analyses of a Head-to-Head Pharmacokinetic Study of Damoctocog Alfa Pegol (BAY 94-9027) and Efmoroctocog Alfa (rFVIIIFc) in Patients with Severe Hemophilia A","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Medicine; Pharmacokinetics; Certolizumab pegol; Crossover study; Bioequivalence; Pharmacology; Potency; Internal medicine; Placebo; Chemistry; Infliximab; Tumor necrosis factor alpha","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001307247,0.0003749847,0.0007267566,0.000347342,0.00024182,0.0005991252,0.0002558712,0.0004043009,0.001178556],"category_scores_gemma":[0.002886419,0.0001815496,0.0008433918,0.0004594681,0.0004405798,0.0003943791,0.0002802706,0.0007029601,0.0002669524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000740561,"about_ca_system_score_gemma":0.0007649427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001116571,"about_ca_topic_score_gemma":0.0007686081,"domain_scores_codex":[0.9989715,0.000398372,0.00005713874,0.0002926478,0.0001848173,0.00009559507],"domain_scores_gemma":[0.9981768,0.0006751222,0.0004423761,0.0002508942,0.0001375345,0.000317255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2239939,0.005717915,0.4356155,0.0006914429,0.004473164,0.002074004,0.001368405,0.0151516,0.1500371,0.000862301,0.001836273,0.1581784],"study_design_scores_gemma":[0.004548327,0.1056168,0.8171269,0.00001659468,0.002641029,0.003308761,0.000238895,0.01481499,0.04278939,0.0003339613,0.008442124,0.0001221738],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975898,0.0005719872,0.0007933812,0.00001404456,0.000007156662,0.0001078631,0.0003458382,0.00002976351,0.0005401936],"genre_scores_gemma":[0.9988409,0.00007605673,0.0003944161,0.00003150449,0.00001312938,0.00004361981,0.0004001659,0.00001000041,0.0001902852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001307247,"threshold_uncertainty_score":0.006913483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05811308316360765,"score_gpt":0.3486165932118195,"score_spread":0.2905035100482118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}