{"id":"W3095006759","doi":"10.1182/blood-2020-135883","title":"Outcome By Mutation Status and Line of Treatment in Optic, a Dose-Ranging Study of 3 Starting Doses of Ponatinib in Patients with CP-CML","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Ponatinib; Medicine; Maximum tolerated dose; Internal medicine; Oncology; Dasatinib; Adverse effect; Imatinib; Myeloid leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001028808,0.000634914,0.0009879355,0.0003899245,0.0003445533,0.0008953738,0.0005353211,0.0007676314,0.002128951],"category_scores_gemma":[0.0008719524,0.0003321657,0.00167334,0.0003071973,0.0007012552,0.0008020225,0.000488524,0.001495346,0.0003607473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001301691,"about_ca_system_score_gemma":0.001329989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001037667,"about_ca_topic_score_gemma":0.003337021,"domain_scores_codex":[0.9994173,0.0001643886,0.00003554523,0.0001489144,0.00009491781,0.0001389924],"domain_scores_gemma":[0.9990081,0.00009361855,0.0002749987,0.00006785292,0.0000450741,0.0005104356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8322083,0.01205248,0.107217,0.0002322803,0.001717647,0.0001703319,0.0002430551,0.001063206,0.009960052,0.0001841811,0.002103639,0.0328478],"study_design_scores_gemma":[0.1743764,0.4390741,0.373954,0.0000733384,0.001700957,0.0004547182,0.0001742398,0.00169278,0.003521355,0.0003671052,0.004496208,0.0001147044],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979007,0.0003265665,0.00006212833,0.00007786345,0.00001666478,0.0002437361,0.0005911872,0.000009007557,0.000772204],"genre_scores_gemma":[0.9969189,0.0001714232,0.0001696945,0.0002913733,0.00004904805,0.0003195194,0.001315427,0.000004095536,0.0007604433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002128951,"threshold_uncertainty_score":0.009444475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01917147793811123,"score_gpt":0.272747336042538,"score_spread":0.2535758581044267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}