{"id":"W3095013795","doi":"10.1182/blood-2020-134928","title":"Sustained Minimal Residual Disease (MRD) Negativity and Clinical Efficacy in Transplant-Ineligible (TIE) Newly Diagnosed Multiple Myeloma (NDMM) Patients (Pts) Treated with Daratumumab-Based Regimens: Analysis of Maia and Alcyone","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Calgary","funders":"","keywords":"Daratumumab; Multiple myeloma; Medicine; Minimal residual disease; Internal medicine; Bortezomib; Oncology; Surgery; Negativity effect; Melphalan; Bone marrow; Psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005870725,0.0001945935,0.0004233459,0.0003379678,0.0002347132,0.000558539,0.0002155004,0.0002372273,0.00109203],"category_scores_gemma":[0.000956343,0.0001143978,0.0004823828,0.0003999136,0.0002312591,0.0002929324,0.000373999,0.000401693,0.0001548546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000356425,"about_ca_system_score_gemma":0.0002402133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004349739,"about_ca_topic_score_gemma":0.000705883,"domain_scores_codex":[0.9998029,0.00005178081,0.00002645795,0.00004967768,0.00003654603,0.0000326073],"domain_scores_gemma":[0.9991196,0.0001497466,0.0004444498,0.00003406628,0.00003470774,0.0002174267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02125854,0.0007300248,0.9585593,0.0001066387,0.0002785194,0.0002335408,0.00009445362,0.0003097434,0.00388851,0.00004296486,0.0001999387,0.01429774],"study_design_scores_gemma":[0.000763442,0.009497828,0.9856374,0.00001789214,0.0002341135,0.001382665,0.00009121706,0.0005925178,0.0008238138,0.00004044746,0.0009089395,0.000009768087],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993665,0.0002774091,0.00004081121,0.00001478981,0.000002847155,0.00001476227,0.000129656,0.000001990996,0.0001512985],"genre_scores_gemma":[0.9993296,0.00009789655,0.0001024492,0.00002712021,0.000009953341,0.0000210752,0.0002975241,0.00000100012,0.0001133971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00109203,"threshold_uncertainty_score":0.003653169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02447451623414271,"score_gpt":0.2938093453074853,"score_spread":0.2693348290733426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}