{"id":"W3095028771","doi":"10.1182/blood-2020-141318","title":"The Fares Study: A Multicenter, Randomized, Active-Control, Pragmatic, Phase 2 Pilot Study Comparing Prothrombin Complex Concentrate Versus Frozen Plasma in Bleeding Adult Cardiac Surgical Patients","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Trauma, Hemostasis, Coagulopathy, Resuscitation","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Toronto General Hospital; University of Toronto; Health Sciences Centre; University Health Network","funders":"","keywords":"Medicine; Fresh frozen plasma; Surgery; Clinical endpoint; Prothrombin complex concentrate; Randomized controlled trial; Packed red blood cells; Blood product; Hemostasis; Partial thromboplastin time; Coagulopathy; Randomization; Blood transfusion; Coagulation; Internal medicine; Warfarin; Atrial fibrillation; Platelet","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007879091,0.003484701,0.004116285,0.0007039973,0.0007613059,0.001360978,0.001393982,0.003869772,0.01022166],"category_scores_gemma":[0.006090671,0.001117243,0.002627178,0.0004875536,0.002087961,0.002067871,0.0007943799,0.003147802,0.001316195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007793498,"about_ca_system_score_gemma":0.002443105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005994864,"about_ca_topic_score_gemma":0.0009603025,"domain_scores_codex":[0.9964086,0.002552885,0.0001503131,0.0004050009,0.0002028457,0.0002803816],"domain_scores_gemma":[0.9967695,0.001136493,0.0006678785,0.0002593008,0.0002339777,0.0009327573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9695224,0.02045372,0.0006344018,0.0004578465,0.0006004886,0.00005556602,0.0000614528,0.0002129157,0.001521946,0.0001498691,0.0007346914,0.005594669],"study_design_scores_gemma":[0.9346378,0.0642956,0.0004668097,0.00001277837,0.00009635643,0.00001238737,0.0000110692,0.00007918743,0.00008935112,0.00006040888,0.0002308472,0.000007303827],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9462384,0.002896472,0.002270727,0.002123444,0.001136931,0.03927581,0.002594311,0.0002037773,0.003259995],"genre_scores_gemma":[0.9223091,0.002379708,0.008414562,0.004776027,0.001610045,0.05337429,0.00226939,0.00006196296,0.004804845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01022166,"threshold_uncertainty_score":0.04166913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04869150278007445,"score_gpt":0.316348576830991,"score_spread":0.2676570740509166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}