{"id":"W3095052296","doi":"10.1101/2020.10.27.357723","title":"Rag GTPases and Phosphatidylinositol 3-Phosphate Mediate Recruitment of the AP-5/SPG11/SPG15 Complex","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sinai Health System; Lunenfeld-Tanenbaum Research Institute","funders":"Cambridge Institute for Medical Research, University of Cambridge; Government of Ontario; Canadian Institutes of Health Research; Genome Canada; Ontario Genomics; Parkinson Canada; Wellcome Trust","keywords":"Endosome; Phosphatidylinositol; mTORC1; GTPase; Cell biology; Lysosome; Signal transducing adaptor protein; Autophagy; Biology; Chemistry; Phosphorylation; Signal transduction; Biochemistry; PI3K/AKT/mTOR pathway; Enzyme; Intracellular","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002528433,0.0003850376,0.0001476679,0.0002371909,0.0001957934,0.000540423,0.000304545,0.0003538428,0.00213468],"category_scores_gemma":[0.0002386629,0.0002379688,0.0003384442,0.0001110049,0.0002080126,0.0003101965,0.0006547984,0.0003747367,0.0009742141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005401135,"about_ca_system_score_gemma":0.0002513507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006929206,"about_ca_topic_score_gemma":0.0007444304,"domain_scores_codex":[0.9997424,0.00005269397,0.00002514765,0.00004339062,0.00007358067,0.00006281846],"domain_scores_gemma":[0.9998759,0.00001471585,0.000022972,0.00001453002,0.00001347089,0.00005831178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000179073,0.00001694371,0.001064411,0.00004466245,0.00001133178,0.000155403,0.00001191014,0.00007080525,0.9968531,0.0002923538,0.000100101,0.001199934],"study_design_scores_gemma":[0.00004316583,0.00012561,0.02342041,0.00001752669,0.00002450592,0.0005961059,0.00006518081,0.005385648,0.9660648,0.000238098,0.004013463,0.000005494554],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926196,0.00188583,0.003124051,0.0001692133,0.0000358787,0.00002522601,0.000234894,0.00009903822,0.001806389],"genre_scores_gemma":[0.995728,0.0003811827,0.001600727,0.00004483639,0.000007453031,0.00002399713,0.0003437911,0.00001069487,0.001859348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00213468,"threshold_uncertainty_score":0.007141232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02984384058351071,"score_gpt":0.2331391128841835,"score_spread":0.2032952723006728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}