{"id":"W3095055739","doi":"10.3389/fnagi.2020.580633","title":"Associating Type 2 Diabetes Risk Factor Genes and FDG-PET Brain Metabolism in Normal Aging and Alzheimer’s Disease","year":2020,"lang":"en","type":"article","venue":"Frontiers in Aging Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Health and Social Services Centre University Institute of Geriatrics of Sherbrooke; Institut Universitaire en Santé Mentale de Québec","funders":"Janssen Alzheimer Immunotherapy Research And Development; Johnson and Johnson Pharmaceutical Research and Development; Fonds de Recherche du Québec - Santé; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Disease; Diabetes mellitus; Single-nucleotide polymorphism; Type 2 diabetes; Gene; Risk factor; Oncology; Medicine; Internal medicine; Biology; Bioinformatics; Endocrinology; Genetics; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006358321,0.0003567344,0.0003448287,0.0007550616,0.0002364251,0.0004846206,0.0002032027,0.0002956646,0.00152259],"category_scores_gemma":[0.001396215,0.0001365382,0.0006148264,0.001320102,0.000265675,0.0001224688,0.0001819461,0.0002927629,0.0001973568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000237217,"about_ca_system_score_gemma":0.0002626041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004015408,"about_ca_topic_score_gemma":0.004502567,"domain_scores_codex":[0.9996381,0.0000821112,0.00003994471,0.0001391346,0.00006101678,0.00003973408],"domain_scores_gemma":[0.9992535,0.000304211,0.0002545244,0.000075894,0.00006558758,0.00004624139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003470315,0.00001982442,0.9899307,0.00004280666,0.0003731593,0.0002301506,0.00004200505,0.0003291886,0.003441454,0.00005553569,0.0001668343,0.00502119],"study_design_scores_gemma":[0.000008120099,0.00003289302,0.9971073,0.000007540595,0.0001859873,0.0004184274,0.00003016246,0.0009148512,0.0007987426,0.0001345243,0.0003576036,0.000003867793],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956679,0.001625585,0.001277686,0.00007294701,0.00001364409,0.00001024605,0.0009137358,0.00002470842,0.0003934541],"genre_scores_gemma":[0.9977736,0.0003264277,0.0009445652,0.00002528725,0.00001243068,0.0000123736,0.0006595688,0.000007896413,0.000237901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004015408,"threshold_uncertainty_score":0.007984102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02913912068611848,"score_gpt":0.2920230618035842,"score_spread":0.2628839411174657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}