{"id":"W3095073252","doi":"10.3390/vaccines8040654","title":"Rapid High-Yield Production of Functional SARS-CoV-2 Receptor Binding Domain by Viral and Non-Viral Transient Expression for Pre-Clinical Evaluation","year":2020,"lang":"en","type":"article","venue":"Vaccines","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Jewish General Hospital; National Research Council Canada; McGill University","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Canada Foundation for Innovation","keywords":"Monoclonal antibody; Transfection; Antibody; Cell culture; Biology; Epitope; Virology; Protein subunit; Coronavirus; Bioprocess; Antigen; Chemistry; Biochemistry; Coronavirus disease 2019 (COVID-19); Immunology; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009763337,0.0001730813,0.0003706074,0.0001186806,0.00009905127,0.00001950434,0.00007857053,0.000159822,0.00003869338],"category_scores_gemma":[0.0008607074,0.0001394791,0.0001292565,0.0002113364,0.00004570954,0.0001840674,0.00003686794,0.0002044227,0.00001175818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004477504,"about_ca_system_score_gemma":0.0001575476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002306536,"about_ca_topic_score_gemma":0.000004203835,"domain_scores_codex":[0.9980708,0.0001108673,0.0005270713,0.0005295485,0.0005294122,0.0002323121],"domain_scores_gemma":[0.9991462,0.0001961613,0.0001408767,0.0001933494,0.0002758824,0.00004751436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004159484,0.0001876353,0.006998786,0.000253644,0.00005568426,4.752515e-7,0.0003493813,0.000001249822,0.92729,0.000004557869,0.04822504,0.01247412],"study_design_scores_gemma":[0.004837038,0.001839019,0.00957533,0.0001556796,0.000117463,0.000004493807,0.0001265883,0.001450237,0.9517533,0.00007854014,0.02990448,0.0001577867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991891,0.0004232849,0.001931556,0.0034205,0.0006567389,0.001550319,0.00003087727,0.00004450477,0.00005123822],"genre_scores_gemma":[0.9945421,0.00002660954,0.00099521,0.002923337,0.001169554,0.0001894959,0.00008962833,0.00002995106,0.00003406284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0244634,"threshold_uncertainty_score":0.5687792,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09515417675117312,"score_gpt":0.3835728753605845,"score_spread":0.2884186986094114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}