{"id":"W3095073252","doi":"10.3390/vaccines8040654","title":"Rapid High-Yield Production of Functional SARS-CoV-2 Receptor Binding Domain by Viral and Non-Viral Transient Expression for Pre-Clinical Evaluation","year":2020,"lang":"en","type":"article","venue":"Vaccines","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Jewish General Hospital; National Research Council Canada; McGill University","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Canada Foundation for Innovation","keywords":"Monoclonal antibody; Transfection; Antibody; Cell culture; Biology; Epitope; Virology; Protein subunit; Coronavirus; Bioprocess; Antigen; Chemistry; Biochemistry; Coronavirus disease 2019 (COVID-19); Immunology; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007033679,0.0005448561,0.0005064563,0.0002353036,0.0001705267,0.0006371721,0.0003786173,0.0004319777,0.001102673],"category_scores_gemma":[0.0003833166,0.0001952034,0.0005801512,0.0002131205,0.0002406328,0.0003507638,0.0004544177,0.0006926249,0.0009969187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003931841,"about_ca_system_score_gemma":0.0002370567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000236751,"about_ca_topic_score_gemma":0.0003499179,"domain_scores_codex":[0.9995435,0.00008387047,0.00004056414,0.00007909376,0.0001986421,0.00005438026],"domain_scores_gemma":[0.9998019,0.00004459976,0.00004569549,0.00003734287,0.0000496637,0.00002080189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002265447,0.00002091885,0.00005934533,0.00003485719,0.000002952287,0.00001791518,0.00001023195,0.00007580885,0.9984036,0.00004630621,0.00002965486,0.001275776],"study_design_scores_gemma":[0.000005240331,0.0001243492,0.0004265909,0.000004613031,0.000008206701,0.00006897781,0.00001159585,0.0005727014,0.9970009,0.00002579598,0.001745685,0.000005357515],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8449301,0.003837405,0.1449373,0.000336707,0.0001437171,0.000368849,0.001770954,0.0008438521,0.002831087],"genre_scores_gemma":[0.8857294,0.002989115,0.09978023,0.0001760277,0.00003913128,0.0004000521,0.004796143,0.0002626705,0.005827128],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001102673,"threshold_uncertainty_score":0.003719807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09515417675117312,"score_gpt":0.3835728753605845,"score_spread":0.2884186986094114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}