{"id":"W3095103767","doi":"10.1161/res.127.suppl_1.mp125","title":"Abstract MP125: Branched-chain Keto Acids, Not Branched-chain Amino Acids, Impairs Cardiac Insulin Sensitivity by Disrupting Insulin Signaling in the Mitochondria","year":2020,"lang":"en","type":"article","venue":"Circulation Research","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Internal medicine; Endocrinology; Insulin resistance; Insulin; Protein kinase B; Cardiac function curve; Glucose uptake; Mitochondrion; Glycolysis; Pyruvate dehydrogenase complex; Carbohydrate metabolism; Insulin receptor; Biology; Chemistry; Metabolism; Medicine; Phosphorylation; Enzyme; Biochemistry; Heart failure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.005841023,0.0004060021,0.0008065354,0.0003618139,0.0004326002,0.0001828231,0.0003057733,0.0004073335,0.0001468945],"category_scores_gemma":[0.003497784,0.0003521578,0.0002904467,0.001720092,0.0002632745,0.0003929183,0.0001530814,0.00212355,0.0002854264],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001913421,"about_ca_system_score_gemma":0.000340966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006562684,"about_ca_topic_score_gemma":0.0000448131,"domain_scores_codex":[0.9936635,0.001509814,0.0008981255,0.0009492887,0.001899812,0.001079412],"domain_scores_gemma":[0.9964945,0.00160099,0.0002040647,0.0007293262,0.0004535687,0.0005175142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006118647,0.0003021029,0.04324739,0.0003915984,0.0001337324,0.0003738143,0.01476381,0.001441791,0.8916667,0.0002085177,0.001731652,0.04512709],"study_design_scores_gemma":[0.005050418,0.0002444516,0.921719,0.0003910383,0.0001453592,0.00005961018,0.006672389,0.01550325,0.03718006,0.0003425133,0.01185158,0.000840372],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833573,0.003544609,0.0008767748,0.009022438,0.0002141825,0.002022769,0.00009804243,0.0001308343,0.0007331258],"genre_scores_gemma":[0.9963634,0.000215386,0.0003028894,0.001266651,0.001258272,0.000103637,0.0003042902,0.00008827423,0.00009721492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8784716,"threshold_uncertainty_score":0.9998931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06661185250283432,"score_gpt":0.3463560557662512,"score_spread":0.2797442032634169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}