{"id":"W3095129474","doi":"10.33218/001c.17956","title":"Effect of major tumor metabolites on release of doxorubicin from Doxil – implications for precision nano-medicine.","year":2020,"lang":"en","type":"article","venue":"Precision Nanomedicine","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Hebrew University of Jerusalem","keywords":"Glutaminolysis; Doxorubicin; Glutaminase; Glutamine; Downregulation and upregulation; Chemistry; Cancer research; Transporter; Pharmacology; Biochemistry; Biology; Medicine; Internal medicine; Chemotherapy; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002984316,0.0001859057,0.0002068881,0.0001213755,0.00006779287,0.0002801632,0.0001399648,0.0002197561,0.002048243],"category_scores_gemma":[0.0004092937,0.0001314354,0.000277934,0.00008635854,0.0001242462,0.000401459,0.0001368013,0.0002942042,0.0003671763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000202784,"about_ca_system_score_gemma":0.0001038779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004822244,"about_ca_topic_score_gemma":0.0006724387,"domain_scores_codex":[0.9998841,0.00002494678,0.000008234156,0.00002630624,0.00003383756,0.00002248974],"domain_scores_gemma":[0.9997777,0.000106919,0.00005459824,0.00001494199,0.00001874623,0.00002711623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008629946,0.00006251562,0.000733017,0.0001499354,0.00001934388,0.00005480272,0.00002033737,0.0003685908,0.9900824,0.00007386696,0.0002030262,0.007369092],"study_design_scores_gemma":[0.00002204114,0.0006506208,0.004797813,0.000008688518,0.00002094182,0.00008141502,0.00001738533,0.002603181,0.9901527,0.00004377614,0.001591621,0.000009878073],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816414,0.008402667,0.004840834,0.0002989382,0.00007047164,0.00007126875,0.001139961,0.0001875337,0.003346967],"genre_scores_gemma":[0.9932834,0.002067166,0.002507049,0.000102757,0.000007314709,0.00002572888,0.0004334891,0.00005163726,0.001521489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002048243,"threshold_uncertainty_score":0.00685209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01301269710980021,"score_gpt":0.2880167261636524,"score_spread":0.2750040290538522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}