{"id":"W3095151225","doi":"10.1182/blood-2020-140408","title":"Adore: A Randomized, Open-Label, Phase 1/2 Open-Platform Study Evaluating Safety and Efficacy of Novel Ruxolitinib Combinations in Patients with Myelofibrosis","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Ruxolitinib; Myelofibrosis; Open label; Medicine; Phases of clinical research; Randomized controlled trial; Internal medicine; Clinical trial; Oncology; Surgery; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001789979,0.00156005,0.002677346,0.0004803078,0.0004225917,0.00130732,0.0008748732,0.001659543,0.01003326],"category_scores_gemma":[0.001169809,0.0005577453,0.001810925,0.0003759567,0.0009120479,0.001452968,0.0004960253,0.002647619,0.001458939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006766923,"about_ca_system_score_gemma":0.0009919821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003815626,"about_ca_topic_score_gemma":0.001104103,"domain_scores_codex":[0.9993545,0.0002981146,0.00003696578,0.0001404022,0.00005408575,0.0001159692],"domain_scores_gemma":[0.9992925,0.0001413879,0.0001735671,0.00005275687,0.00005720422,0.0002825834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8985643,0.03044832,0.002029586,0.001886425,0.001865239,0.0001351341,0.00009070525,0.0007040072,0.007302955,0.0003394719,0.003535189,0.05309874],"study_design_scores_gemma":[0.8878469,0.1057157,0.002270526,0.00005904607,0.0005417899,0.0001174572,0.00003081195,0.0004240186,0.0004124898,0.0001925833,0.002367066,0.00002163707],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9625129,0.01440538,0.001270447,0.001503971,0.00101767,0.01058614,0.003360568,0.0002523849,0.005090614],"genre_scores_gemma":[0.963863,0.006128514,0.003311011,0.002963946,0.0008247898,0.01299119,0.003453705,0.00003205471,0.00643181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01003326,"threshold_uncertainty_score":0.03356457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07703137770199205,"score_gpt":0.3677363953716987,"score_spread":0.2907050176697067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}