{"id":"W3095178928","doi":"10.1182/blood-2020-136004","title":"A Phase 2 Open-Label, Multicenter, Dose Optimization Clinical Study of the Safety, Tolerability, and Pharmacokinetic (PK) and Pharmacodynamic (PD) Profiles of Cfi-400945 As a Single Agent or in Combination with Azacitidine or Decitabine in Patients with Acute Myeloid Leukemia","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Alberta","funders":"","keywords":"Tolerability; Medicine; Pharmacodynamics; Oncology; Myeloid leukemia; Leukemia; Internal medicine; Phases of clinical research; Cancer; Clinical trial; Pharmacology; Pharmacokinetics; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001288834,0.001559576,0.002103351,0.0005871737,0.0004573153,0.000856282,0.001010458,0.001330111,0.003984773],"category_scores_gemma":[0.001058929,0.0005905982,0.0009028147,0.0006194418,0.001142617,0.001184138,0.0003881512,0.003412476,0.0007718803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00132233,"about_ca_system_score_gemma":0.001381369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009129973,"about_ca_topic_score_gemma":0.00171745,"domain_scores_codex":[0.9994803,0.0001900593,0.00002373525,0.0001361391,0.00005863354,0.0001111971],"domain_scores_gemma":[0.9993475,0.0001020203,0.0001573759,0.00009323758,0.00004604094,0.0002538272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6006497,0.1284949,0.006043632,0.0006364925,0.001129052,0.0003765519,0.0005184265,0.00641235,0.1070418,0.0005084598,0.00411349,0.1440751],"study_design_scores_gemma":[0.3434336,0.6306326,0.01185945,0.00002240361,0.000270997,0.0003949456,0.00007087227,0.001999794,0.007931122,0.0002564582,0.003078095,0.00004964167],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941203,0.001091134,0.0007106868,0.0002195696,0.00005284351,0.001874468,0.0007972047,0.0001011073,0.001032624],"genre_scores_gemma":[0.9900534,0.0008539648,0.002410758,0.0004862976,0.0001014388,0.002422038,0.001911453,0.00003704876,0.001723773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003984773,"threshold_uncertainty_score":0.0133304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02470530185518123,"score_gpt":0.3170932936291024,"score_spread":0.2923879917739212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}