{"id":"W3095213530","doi":"10.1182/blood-2020-142671","title":"Dichotomous Regulation of Lysosomes By MYC and Tfeb Controls Hematopoietic Stem Cell Fate","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto; University Health Network","funders":"","keywords":"Cell biology; Stem cell; Haematopoiesis; Biology; Hematopoietic stem cell; Progenitor cell; Cell fate determination; Endocytosis; Cell; Biochemistry; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001787365,0.0001843177,0.0002281101,0.0002755864,0.000140719,0.0006011251,0.0001929781,0.0002806706,0.0009874089],"category_scores_gemma":[0.0002582693,0.0001451099,0.000194946,0.0001120443,0.0003423029,0.0004755444,0.0004125636,0.0003648578,0.0004298571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000430895,"about_ca_system_score_gemma":0.0001412678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002496868,"about_ca_topic_score_gemma":0.0004351108,"domain_scores_codex":[0.9997908,0.00003041284,0.00001780229,0.00005899525,0.00002650159,0.00007558442],"domain_scores_gemma":[0.9997829,0.00003575301,0.00006055655,0.00001782345,0.00002376019,0.00007932341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003203977,0.00001531176,0.001061805,0.00003018598,0.000003390247,0.00007417742,0.00003959783,0.00006320858,0.9960802,0.0003848201,0.00006137689,0.001865612],"study_design_scores_gemma":[0.00005271754,0.0002641426,0.03364324,0.00001508941,0.00002079825,0.000487323,0.0002179435,0.003239074,0.9570791,0.000437588,0.00452623,0.00001680295],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930639,0.002432867,0.00233407,0.00008499358,0.00002945906,0.000008344586,0.0002259014,0.00009080437,0.00172963],"genre_scores_gemma":[0.9976132,0.0004873204,0.0004805501,0.00002788433,0.000009583575,0.00001342885,0.0001430225,0.00001764805,0.001207347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009874089,"threshold_uncertainty_score":0.00330323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008574327165201163,"score_gpt":0.2188745827493976,"score_spread":0.2103002555841965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}