{"id":"W3095224165","doi":"10.1182/blood-2020-141740","title":"A Stemness-Based Screen Identifies PLK1 Inhibitors for Targeting Leukemia Stem Cells in AML","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Stem cell; CD38; Leukemia; Myeloid leukemia; Cancer research; CD34; PLK1; Biology; Immunology; Cell; Cell cycle; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002622626,0.001141519,0.001101788,0.001398024,0.0003036808,0.0005548661,0.0004494579,0.0004579076,0.002991355],"category_scores_gemma":[0.0002886284,0.0003099627,0.0005366711,0.0009169456,0.0002285751,0.0002252876,0.0004297257,0.0006417258,0.0007483577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005515976,"about_ca_system_score_gemma":0.0005566576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007647069,"about_ca_topic_score_gemma":0.002905141,"domain_scores_codex":[0.9997485,0.00002279263,0.00002018056,0.00006340204,0.00009246963,0.00005266857],"domain_scores_gemma":[0.9998789,0.00002862614,0.00002329389,0.00000935676,0.00002281517,0.00003709451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007472789,0.0004994494,0.001809619,0.0004299526,0.00009819489,0.0003563289,0.00005859594,0.002340518,0.967158,0.0002393181,0.0007893332,0.02547345],"study_design_scores_gemma":[0.000785463,0.01091005,0.01790207,0.0001164685,0.0005415656,0.001520287,0.000096357,0.005100609,0.9480364,0.000248014,0.01467114,0.00007156016],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9720598,0.00669317,0.005482229,0.0003402549,0.00004366941,0.000955727,0.007971858,0.0007226714,0.005730579],"genre_scores_gemma":[0.9668496,0.006973865,0.007498762,0.0003725683,0.00002242283,0.0005318392,0.01145788,0.00008128809,0.006211817],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002991355,"threshold_uncertainty_score":0.01000708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02953190450137238,"score_gpt":0.2800257858439322,"score_spread":0.2504938813425598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}