{"id":"W3095236197","doi":"10.1182/blood-2020-142652","title":"Elevated Expression of Mir-130a in t(8,21) AML Reinforces the Aberrant Molecular Program of AML1-ETO","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Corepressor; RUNX1; Myelopoiesis; Cancer research; Biology; Myeloid leukemia; Haematopoiesis; Myeloid; microRNA; Leukemia; Vorinostat; Stem cell; Cell biology; Repressor; Histone; Histone deacetylase; Immunology; Gene expression; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001094875,0.0001963941,0.000134873,0.0002815097,0.0001304826,0.0002489682,0.0001070576,0.000211226,0.001453331],"category_scores_gemma":[0.0001604336,0.0001062444,0.0001857817,0.0001569282,0.0001993808,0.0001665608,0.0001995165,0.0004187707,0.0005247959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002592418,"about_ca_system_score_gemma":0.0001425411,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002245007,"about_ca_topic_score_gemma":0.000324832,"domain_scores_codex":[0.9998783,0.00001084255,0.00001120919,0.00002885025,0.00004166665,0.00002912321],"domain_scores_gemma":[0.9998825,0.00001738596,0.00004955936,0.000007551838,0.00001401178,0.00002893298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007341485,0.00001596773,0.0006165241,0.00001340467,0.000002278162,0.0000760313,0.00001094372,0.00003135119,0.9983287,0.00007845123,0.00001961125,0.0007332469],"study_design_scores_gemma":[0.00001938536,0.000463419,0.02226042,0.000005910826,0.00002537991,0.001958376,0.00004749729,0.001163401,0.9679143,0.0002004603,0.005934422,0.000007153451],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995926,0.0005417366,0.001617833,0.0000438496,0.00001676827,0.00002729875,0.0003154018,0.00005939752,0.001451742],"genre_scores_gemma":[0.9960895,0.0002923568,0.002046694,0.00003402803,0.000007610362,0.00002374042,0.000428947,0.00001603089,0.00106114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001453331,"threshold_uncertainty_score":0.004861891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008750890709371876,"score_gpt":0.238349117195876,"score_spread":0.2295982264865041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}