{"id":"W3095264723","doi":"10.1182/blood-2020-136465","title":"A Phase I Study of Anti-ICOS Antibody MEDI-570 for Relapsed/Refractory (R/R) Peripheral T-Cell Lymphoma (PTCL) and Angioimmunoblastic T-Cell Lymphoma (AITL) (NCI-9930)","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Angioimmunoblastic T-cell lymphoma; Lymphoma; Peripheral T-cell lymphoma; Germinal center; Mycosis fungoides; T cell; Neutropenia; Follicular lymphoma; Internal medicine; Antibody; Cancer research; Oncology; Immunology; Immune system; Chemotherapy; B cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008261746,0.001125224,0.001165245,0.0004591345,0.000352707,0.0005572546,0.001040042,0.0008489066,0.003382593],"category_scores_gemma":[0.000397229,0.0004695032,0.0006189794,0.0003385013,0.0006794459,0.0004752731,0.0002337823,0.002058178,0.0009807873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007473084,"about_ca_system_score_gemma":0.0014736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001485355,"about_ca_topic_score_gemma":0.003399065,"domain_scores_codex":[0.9998147,0.00006620425,0.00001052113,0.00003450255,0.00002807173,0.00004599701],"domain_scores_gemma":[0.9996256,0.00004741145,0.00006559142,0.00003836514,0.00003006009,0.0001930949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4344998,0.141127,0.010684,0.001733273,0.001166893,0.001002947,0.0005493516,0.005251452,0.244731,0.0009309032,0.005892999,0.1524304],"study_design_scores_gemma":[0.2154765,0.7505108,0.01213319,0.00004655869,0.0004089243,0.0007959091,0.00009034136,0.001647717,0.01458191,0.0001740977,0.004108377,0.00002564006],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923153,0.001015564,0.0005420464,0.000149799,0.00004466951,0.002904225,0.0007308208,0.0001150674,0.002182494],"genre_scores_gemma":[0.9888154,0.001529434,0.001780214,0.0004024845,0.00008215049,0.00258144,0.002003021,0.00002942476,0.00277648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003382593,"threshold_uncertainty_score":0.01131588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02325757519943895,"score_gpt":0.3046426809321946,"score_spread":0.2813851057327557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}