{"id":"W3095303989","doi":"10.1007/s10549-020-05989-5","title":"Response to neoadjuvant chemotherapy and the 21-gene Breast Recurrence Score test in young women with estrogen receptor-positive early breast cancer","year":2020,"lang":"en","type":"article","venue":"Breast Cancer Research and Treatment","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Breast cancer; Medicine; Internal medicine; Estrogen receptor; Oncology; Chemotherapy; Cancer; Logistic regression; Stage (stratigraphy); Estrogen; Cohort; Pathological; Prospective cohort study; Gynecology; Gastroenterology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003519479,0.0004477313,0.0004541928,0.00009593535,0.0003376525,0.0001236068,0.000231224,0.00009761511,0.00005160113],"category_scores_gemma":[0.00002466518,0.0002819391,0.00004959928,0.0005224376,0.0007023702,0.00002278411,0.0002287049,0.0001975054,0.000007853942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005933853,"about_ca_system_score_gemma":0.0005040779,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01023372,"about_ca_topic_score_gemma":0.002171256,"domain_scores_codex":[0.9971678,0.0002840729,0.000242398,0.001002521,0.0004280792,0.0008751688],"domain_scores_gemma":[0.9985917,0.000131483,0.00007719929,0.0003670754,0.0002985786,0.00053401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1529429,0.0006206767,0.6875457,0.00003442575,0.001033557,0.00006719215,0.007832907,0.00002369068,0.03448716,0.00002769164,0.0003871515,0.114997],"study_design_scores_gemma":[0.01152111,0.002217027,0.9756765,0.0002086213,0.00003992796,0.0004437129,0.0008872738,0.000008676853,0.008107249,0.00001612707,0.0005060675,0.0003677522],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9500155,0.003015055,0.000005593515,0.04225438,0.00003227022,0.00122127,0.003393859,0.0000175779,0.00004451143],"genre_scores_gemma":[0.9910218,0.005345327,0.00007689425,0.0004345074,0.0002925069,0.002594873,0.00003926268,0.0000564482,0.0001383613],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2881308,"threshold_uncertainty_score":0.9999633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01751918956554794,"score_gpt":0.2950526082072244,"score_spread":0.2775334186416765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}