{"id":"W3095354231","doi":"10.1182/blood-2020-136198","title":"Updates from Ongoing, First-in-Human Phase 1 Dose Escalation and Expansion Study of TTI-621, a Novel Biologic Targeting CD47, in Patients with Relapsed or Refractory Hematologic Malignancies","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trillium Therapeutics (Canada); BC Cancer Agency; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Refractory (planetary science); CD47; Hematologic Neoplasms; Oncology; Leukapheresis; Internal medicine; Intensive care medicine; Cancer; Receptor; Stem cell; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001385978,0.0001800785,0.000423218,0.0001016844,0.00009709584,0.000009219508,0.0001039235,0.0001690953,0.00005762911],"category_scores_gemma":[0.0001314744,0.0001258631,0.00002488043,0.0001959652,0.00007360482,0.0001573859,0.00008151775,0.0001668208,0.000003172521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000172831,"about_ca_system_score_gemma":0.00001902598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001916714,"about_ca_topic_score_gemma":0.0001364801,"domain_scores_codex":[0.9987562,0.0001451634,0.0004935983,0.0003621418,0.00004593391,0.0001969901],"domain_scores_gemma":[0.999372,0.0001164207,0.0002972896,0.0001516833,0.00004531796,0.00001728758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008514279,0.004841263,0.5147255,0.00002484348,0.00006162951,0.000004948901,0.002399584,0.00001419005,0.4768499,0.000008358568,0.00001211581,0.0002062212],"study_design_scores_gemma":[0.03185795,0.004583943,0.9044636,0.0001545141,0.00007202649,0.000001853049,0.00141564,0.00003701865,0.05713494,0.0000154454,0.00005133458,0.0002117674],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985425,0.0007522487,0.00001307942,0.00003385365,0.00003826828,0.0005541957,0.00002580361,0.00003211647,0.000007867097],"genre_scores_gemma":[0.99945,0.00002255102,0.0001217876,0.00002769186,0.000007213189,0.00002491042,0.0003279612,0.00001200808,0.00000591256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4197149,"threshold_uncertainty_score":0.5132546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0196920499174189,"score_gpt":0.2409773554635876,"score_spread":0.2212853055461687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}