{"id":"W3095363841","doi":"10.1210/endocr/bqaa185","title":"Targeting Cancer Cells via N-degron-based PROTACs","year":2020,"lang":"en","type":"article","venue":"Endocrinology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Parkinson Canada","keywords":"Degron; Proteasome; Proteolysis; Context (archaeology); Ubiquitin; Cell biology; Protein degradation; Autophagy; Biology; Chemistry; Biochemistry; Gene; Ubiquitin ligase; Enzyme; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000028233,0.0001300484,0.0001193823,0.00002148189,0.00006219049,0.000009551683,0.0001672525,0.00008634711,0.0002370071],"category_scores_gemma":[0.00006120581,0.0001260284,0.00005763827,0.00007027498,0.00006518797,0.000002520066,0.00007642922,0.0001199398,0.00008100769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001059777,"about_ca_system_score_gemma":0.00007741913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002772912,"about_ca_topic_score_gemma":0.000004861198,"domain_scores_codex":[0.9990672,0.00006114372,0.0001675681,0.0003270875,0.00007404117,0.0003029041],"domain_scores_gemma":[0.9996338,0.000006442281,0.00006752057,0.000151439,0.0000460019,0.00009479083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004671935,0.00002021893,0.001001495,0.000015422,0.00001749555,0.000007266662,0.00001801222,0.0002816564,0.9816945,0.00007338897,0.01378256,0.003041264],"study_design_scores_gemma":[0.0003906128,0.0001599425,0.00007145591,0.000002324753,0.000004992358,0.000001853382,0.00001249428,0.0006157807,0.7955668,0.00001285274,0.2030344,0.0001265566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9405471,0.003721864,0.03276312,0.01658997,0.001344124,0.001353084,0.00006384185,0.0002257099,0.003391205],"genre_scores_gemma":[0.9933211,0.00007919243,0.00135732,0.004287627,0.0004821456,0.0001209197,0.00007812476,0.00002331208,0.0002503127],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1892518,"threshold_uncertainty_score":0.5139287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01357048101814007,"score_gpt":0.247145574415024,"score_spread":0.2335750933968839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}