{"id":"W3095363841","doi":"10.1210/endocr/bqaa185","title":"Targeting Cancer Cells via N-degron-based PROTACs","year":2020,"lang":"en","type":"article","venue":"Endocrinology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Parkinson Canada","keywords":"Degron; Proteasome; Proteolysis; Context (archaeology); Ubiquitin; Cell biology; Protein degradation; Autophagy; Biology; Chemistry; Biochemistry; Gene; Ubiquitin ligase; Enzyme; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001394409,0.0002699724,0.0002033447,0.0001272724,0.0001160481,0.0002526014,0.0001595105,0.0002930008,0.0005078483],"category_scores_gemma":[0.00005991083,0.00008396112,0.0002026163,0.000113594,0.0001583563,0.000191759,0.0002154587,0.0003843626,0.0003152406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003099396,"about_ca_system_score_gemma":0.0001900295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002865753,"about_ca_topic_score_gemma":0.0004203748,"domain_scores_codex":[0.9999275,0.00001318374,0.000005152555,0.00001763661,0.00002338176,0.00001311336],"domain_scores_gemma":[0.9999671,0.000005086534,0.00001123992,0.000004779058,0.000003979982,0.000007934223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007469807,0.00001891452,0.00007326236,0.00007283295,0.000007945591,0.00007754425,0.00001511249,0.0002230681,0.99463,0.0008491486,0.0001328597,0.003824629],"study_design_scores_gemma":[0.00001291912,0.0001971242,0.0004667053,0.000007226922,0.0000125853,0.0005933379,0.00001082498,0.0009602935,0.9763682,0.0001059259,0.02125901,0.000005867461],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9102852,0.02236765,0.05422392,0.0006766939,0.0001907047,0.0002187024,0.0006270069,0.0005691373,0.01084101],"genre_scores_gemma":[0.9569119,0.009137876,0.02456745,0.0002666398,0.00002231766,0.00007869081,0.0005116426,0.00003934753,0.008464099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005078483,"threshold_uncertainty_score":0.002248824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01357048101814007,"score_gpt":0.247145574415024,"score_spread":0.2335750933968839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}