{"id":"W3095389126","doi":"10.1182/blood-2020-136985","title":"Initial Clinical Activity and Safety of BFCR4350A, a FcRH5/CD3 T-Cell-Engaging Bispecific Antibody, in Relapsed/Refractory Multiple Myeloma","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Multiple myeloma; Medicine; Bispecific antibody; Refractory (planetary science); Antibody; Oncology; Daratumumab; Cancer research; Internal medicine; Bortezomib; Immunology; Monoclonal antibody; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000602873,0.0002049355,0.0006459854,0.0001268122,0.00009068257,0.00001351284,0.000139925,0.0001800399,0.000130531],"category_scores_gemma":[0.0005743564,0.0001772217,0.0001684433,0.0003002643,0.0002960869,0.00008238872,0.0002158135,0.001017509,0.00003325593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001525547,"about_ca_system_score_gemma":0.0001894395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002038402,"about_ca_topic_score_gemma":0.00004656126,"domain_scores_codex":[0.9978374,0.0002944266,0.0005943451,0.0004713077,0.0004234653,0.0003790859],"domain_scores_gemma":[0.9983267,0.0008531509,0.0001338365,0.0002334174,0.00007996269,0.0003729899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004609965,0.002166541,0.7856654,0.0005208193,0.0001242176,0.0005942301,0.0008693299,0.000001518174,0.1876222,0.00005117988,0.0001996867,0.01757495],"study_design_scores_gemma":[0.01413835,0.001635255,0.9380487,0.0002368316,0.0001004507,0.00006357964,0.0002520345,0.0009670421,0.03689638,0.00002849915,0.007358512,0.0002744313],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925235,0.0008793492,0.00003112993,0.001756357,0.00008971689,0.0003846045,0.0000555969,0.00003500544,0.004244754],"genre_scores_gemma":[0.9974912,0.001031317,0.0005226066,0.000294213,0.0004281162,0.000006069999,0.00002910735,0.00002764885,0.0001696691],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1523832,"threshold_uncertainty_score":0.7226891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0630330095473095,"score_gpt":0.3613555670925355,"score_spread":0.298322557545226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}