{"id":"W3095393483","doi":"10.1182/blood-2020-136632","title":"Pioneer Part 2: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study to Evaluate Safety and Efficacy of Avapritinib in Indolent Systemic Mastocytosis","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"Systemic mastocytosis; Tolerability; Medicine; Omalizumab; Internal medicine; Placebo; Phases of clinical research; Mast cell; Adverse effect; Pharmacology; Clinical trial; Oncology; Immunology; Pathology; Immunoglobulin E","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002295079,0.002207833,0.003191312,0.0005134264,0.0005347714,0.001122024,0.001274178,0.002971882,0.01194226],"category_scores_gemma":[0.0016121,0.0007774275,0.001887956,0.0003746927,0.001106248,0.001393073,0.0003790566,0.003382471,0.001936815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009408587,"about_ca_system_score_gemma":0.002224143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008274742,"about_ca_topic_score_gemma":0.002172638,"domain_scores_codex":[0.9993739,0.0002429461,0.00003238102,0.0001655899,0.00007961306,0.0001056945],"domain_scores_gemma":[0.9989964,0.0001853221,0.0002570718,0.0000872992,0.0001070161,0.0003667565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9464199,0.0187781,0.0006493494,0.001662139,0.00160874,0.0000979613,0.00007317244,0.0004699957,0.009925533,0.0002624332,0.003366065,0.01668664],"study_design_scores_gemma":[0.9372352,0.05978085,0.0009581639,0.00003231626,0.0002774064,0.0000402583,0.000008025235,0.0001906826,0.0003199414,0.00008972529,0.00105346,0.00001382079],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9309686,0.01371054,0.00236622,0.00191406,0.001373776,0.03525179,0.007126141,0.0007424716,0.006546338],"genre_scores_gemma":[0.929744,0.006287372,0.007928693,0.004319674,0.001308672,0.03370334,0.006151206,0.0001076668,0.01044933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01194226,"threshold_uncertainty_score":0.03995085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02536176728082418,"score_gpt":0.2773973426336132,"score_spread":0.252035575352789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}