{"id":"W3095409250","doi":"10.1182/blood-2020-136250","title":"ENESTop 5-Year Update: Durability of Treatment-Free Remission Following Second-Line Nilotinib and Exploratory Analysis of Molecular Response Regain after Nilotinib Re-Initiation in Patients with Chronic Myeloid Leukemia","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Nilotinib; Medicine; Internal medicine; Myeloid leukemia; Interim analysis; Imatinib mesylate; Imatinib; Neutropenia; Surgery; Gastroenterology; Clinical trial; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006849066,0.0004546959,0.001709629,0.0009362302,0.0001889127,0.001822722,0.001134842,0.00069667,0.00174384],"category_scores_gemma":[0.006848767,0.0002549153,0.001521771,0.001320893,0.000201471,0.001199462,0.0008066879,0.00115084,0.0007047656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009580138,"about_ca_system_score_gemma":0.001276742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001548555,"about_ca_topic_score_gemma":0.005678792,"domain_scores_codex":[0.9978831,0.0008072102,0.0004083321,0.0002184357,0.0005591813,0.0001236221],"domain_scores_gemma":[0.9870364,0.003403148,0.005795936,0.0005120469,0.002517753,0.0007347261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.04553008,0.001021767,0.3251382,0.009711959,0.006427241,0.0003365676,0.0002847293,0.002204808,0.003966354,0.001138627,0.07504842,0.5291911],"study_design_scores_gemma":[0.009531584,0.01432177,0.7639636,0.002803983,0.0115135,0.002038208,0.0002224351,0.002485756,0.00241448,0.0007816774,0.1897767,0.0001462048],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5999734,0.2109111,0.005563269,0.00852423,0.001204348,0.001982324,0.1419318,0.0007471154,0.02916242],"genre_scores_gemma":[0.7550125,0.06107879,0.00830486,0.007035268,0.001811905,0.002751931,0.1570065,0.0002415459,0.006756702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006849066,"threshold_uncertainty_score":0.03622174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01173863773457207,"score_gpt":0.2370372014266214,"score_spread":0.2252985636920493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}