{"id":"W3095419444","doi":"10.1182/blood-2020-141505","title":"Safety and Efficacy of Ex Vivo Expanded Healthy Donor-Derived Double Negative T Cells for the Treatment of AML Relapsed after Allogeneic Stem Cell Transplantation: A First in-Human Phase I/IIa Clinical Trial","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University Health Network","funders":"","keywords":"Medicine; Transplantation; Internal medicine; Clinical trial; Hematopoietic stem cell transplantation; Oncology; Donor lymphocyte infusion; Stem cell; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003522959,0.0001810514,0.000681342,0.00005748737,0.00006315656,0.000008988814,0.00009714359,0.0001196961,0.0002836339],"category_scores_gemma":[0.00001125854,0.0001252961,0.0002560184,0.0001539859,0.000172721,0.00002450956,0.00001337696,0.000132364,0.000001261725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003697929,"about_ca_system_score_gemma":0.0001534824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009569938,"about_ca_topic_score_gemma":0.000170805,"domain_scores_codex":[0.998167,0.0001650815,0.0008320925,0.0003615734,0.0002344379,0.0002398087],"domain_scores_gemma":[0.9979993,0.001264676,0.0001923535,0.0002800341,0.00007334515,0.0001902761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7704435,0.009410352,0.001602344,0.0005514125,0.0004746819,0.00005455687,0.01523625,0.00001114734,0.19756,0.000005600551,0.00002567129,0.004624469],"study_design_scores_gemma":[0.5597146,0.0275557,0.001933941,0.00005745113,0.000566646,0.000003712537,0.0003126971,0.00005730545,0.4083567,0.00000347731,0.00133341,0.0001044314],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934646,0.0006558649,0.00006285703,0.0008857223,0.00007168464,0.004600133,0.0001081331,0.00001354942,0.0001374117],"genre_scores_gemma":[0.9952136,0.003762589,0.0001713736,0.0001069811,0.0002350955,0.0002080939,0.00002506615,0.00002797806,0.0002492273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2107967,"threshold_uncertainty_score":0.5109428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0826160488270848,"score_gpt":0.3805143350510194,"score_spread":0.2978982862239347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}