{"id":"W3095419444","doi":"10.1182/blood-2020-141505","title":"Safety and Efficacy of Ex Vivo Expanded Healthy Donor-Derived Double Negative T Cells for the Treatment of AML Relapsed after Allogeneic Stem Cell Transplantation: A First in-Human Phase I/IIa Clinical Trial","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University Health Network","funders":"","keywords":"Medicine; Transplantation; Internal medicine; Clinical trial; Hematopoietic stem cell transplantation; Oncology; Donor lymphocyte infusion; Stem cell; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001979381,0.001545961,0.002088454,0.0004923649,0.0004369821,0.001207154,0.0009016053,0.00153111,0.002162738],"category_scores_gemma":[0.0006837858,0.0004930287,0.001264537,0.0003523674,0.001093768,0.0007744232,0.0004145036,0.003105714,0.0005730672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006843256,"about_ca_system_score_gemma":0.001163832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003094796,"about_ca_topic_score_gemma":0.0006282057,"domain_scores_codex":[0.9994136,0.0002916646,0.00003990251,0.0001005208,0.00004594775,0.0001083558],"domain_scores_gemma":[0.9995044,0.00006518478,0.0000893305,0.00007076375,0.00003314221,0.0002370647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6816452,0.1076439,0.002936885,0.001455532,0.0009809405,0.0004863727,0.0004311097,0.002553452,0.06634172,0.0005646995,0.00375649,0.1312037],"study_design_scores_gemma":[0.4888139,0.4953895,0.00310947,0.00005594257,0.0003336552,0.0002886965,0.00004552907,0.0008334199,0.0068746,0.0002530055,0.003969461,0.00003284713],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867826,0.004620801,0.0008679781,0.0004345479,0.0002695312,0.004113222,0.001151402,0.0001130907,0.001646839],"genre_scores_gemma":[0.9865162,0.00274843,0.001670557,0.001005409,0.0002334118,0.003942538,0.001738834,0.00002830489,0.002116276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002162738,"threshold_uncertainty_score":0.01046807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0826160488270848,"score_gpt":0.3805143350510194,"score_spread":0.2978982862239347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}