{"id":"W3095446841","doi":"10.3389/fncel.2020.581907","title":"Amyotrophic Lateral Sclerosis: Proteins, Proteostasis, Prions, and Promises","year":2020,"lang":"en","type":"article","venue":"Frontiers in Cellular Neuroscience","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Motor Neurone Disease Research Australia; Motor Neurone Disease Australia; Fondation Brain Canada","keywords":"Proteostasis; Amyotrophic lateral sclerosis; Protein aggregation; Neuroscience; Biology; Neurodegeneration; Cell biology; Cellular pathology; Pathology; Disease; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002646877,0.0002485342,0.0004080735,0.0001719862,0.0001726133,0.0001272506,0.0003399926,0.0001097255,0.00002057551],"category_scores_gemma":[0.0004591823,0.0002095075,0.00006608979,0.0008728602,0.0005269553,0.0003201206,0.0002676588,0.0005594335,0.00001229907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008575655,"about_ca_system_score_gemma":0.0001857254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003524595,"about_ca_topic_score_gemma":9.175415e-7,"domain_scores_codex":[0.9972463,0.0001495136,0.000369956,0.0008809785,0.0007036407,0.0006496508],"domain_scores_gemma":[0.9989735,0.00001116666,0.00008797234,0.0003355386,0.00005728585,0.0005344587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000333241,0.0001379822,0.1083985,0.0002409867,0.000005736689,0.0002620388,0.0003575621,0.00001932757,0.8833368,0.00002886952,0.001302346,0.005576601],"study_design_scores_gemma":[0.006040643,0.00297014,0.7902309,0.0008511966,0.00006360574,0.00008563646,0.0001490429,0.04864607,0.1350787,0.0003199127,0.01454289,0.001021238],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815493,0.001232545,0.003663449,0.0105759,0.0002493794,0.002520987,0.000009520225,0.0001168461,0.00008213208],"genre_scores_gemma":[0.987231,0.0006802394,0.009653935,0.001898885,0.0001068403,0.0001598584,0.00000505755,0.00003866107,0.0002255959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7482581,"threshold_uncertainty_score":0.8543469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05058660574145293,"score_gpt":0.2550611345708801,"score_spread":0.2044745288294272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}