{"id":"W3095446841","doi":"10.3389/fncel.2020.581907","title":"Amyotrophic Lateral Sclerosis: Proteins, Proteostasis, Prions, and Promises","year":2020,"lang":"en","type":"article","venue":"Frontiers in Cellular Neuroscience","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Motor Neurone Disease Research Australia; Motor Neurone Disease Australia; Fondation Brain Canada","keywords":"Proteostasis; Amyotrophic lateral sclerosis; Protein aggregation; Neuroscience; Biology; Neurodegeneration; Cell biology; Cellular pathology; Pathology; Disease; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001174967,0.0005594714,0.0008533286,0.001077065,0.0004339406,0.001586719,0.0005206307,0.00117891,0.0020504],"category_scores_gemma":[0.0006998272,0.000143906,0.0002372635,0.00112035,0.0009189087,0.002542642,0.0008197575,0.001736938,0.001485688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006964198,"about_ca_system_score_gemma":0.0009069351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005054905,"about_ca_topic_score_gemma":0.001205585,"domain_scores_codex":[0.9997616,0.00005859984,0.00002275702,0.00002947504,0.0001008511,0.00002671511],"domain_scores_gemma":[0.9996657,0.0001352293,0.00003692387,0.00001297734,0.0000873895,0.00006179127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003229999,0.0001574912,0.0006816266,0.01451778,0.00009136517,0.0008872073,0.0006333037,0.0006645516,0.02020021,0.04870369,0.09483226,0.8183075],"study_design_scores_gemma":[0.00001328065,0.000185958,0.0008980517,0.002104138,0.00004243004,0.001345765,0.0002450611,0.0001023163,0.001611651,0.0197639,0.9736633,0.00002416282],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004940836,0.9944193,0.0002918321,0.00182713,0.0008565593,0.000005384896,0.00001976906,0.00001450775,0.002071541],"genre_scores_gemma":[0.003517879,0.990379,0.0005451113,0.001223179,0.00115649,0.0000112032,0.00005903037,0.000005275735,0.003102805],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0020504,"threshold_uncertainty_score":0.006859243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05058660574145293,"score_gpt":0.2550611345708801,"score_spread":0.2044745288294272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}